中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 数学与系统科学研究院
  3. 中国科学院数学与系统科学研究院
Characteristics of distribution of Mycobacterium tuberculosis lineages in China

文献类型：期刊论文

作者Chen, Haixia1,2,3; He, Li4,5; Cai, Chao6; Liu, Jingyi1,2,3; Jia, Junnan2,3,6,7; Ma, Liang8; Huang, Hairong2,3,6; Wang, Lixia9; Ni, Xumin10; Gao, Jimin1
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2018-06-01
卷号61期号:6页码:651-659
关键词Mycobacterium tuberculosis Lineage 2 Lineage 4 large sequence polymorphism fever
ISSN号1674-7305
DOI10.1007/s11427-017-9243-0
英文摘要The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905 (2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases (975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages (Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation (farmer), and degree of education (non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment.
资助项目National Natural Science Foundation of China[81273144] ; Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education[KZ201510025024] ; Fundamental Research Funds for the Central Universities[2017JBM071] ; China Postdoctoral Science Foundation[2017M620595]
WOS研究方向Life Sciences & Biomedicine - Other Topics
语种英语
WOS记录号WOS:000435974800005
出版者SCIENCE PRESS
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/30607]  
专题中国科学院数学与系统科学研究院
通讯作者Ni, Xumin; Gao, Jimin; Li, Weimin
作者单位1.Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China
2.Capital Med Univ, Beijing TB & Thorac Tumor Res Inst Beijing Chest, Natl TB Clin Lab China, Beijing 101149, Peoples R China
3.Capital Med Univ, Beijing Chest Hosp, Beijing 101149, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
6.Capital Med Univ, Beijing Chest Hosp, Beijing Key Lab Drug Resistance TB Res, Beijing 101149, Peoples R China
7.Capital Med Univ, Beijing Municipal Key Lab Clin Epidemiol, Sch Publ Hlth, Beijing 100069, Peoples R China
8.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China
9.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 102206, Peoples R China
10.Beijing Jiaotong Univ, Sch Sci, Dept Math, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Haixia,He, Li,Cai, Chao,et al. Characteristics of distribution of Mycobacterium tuberculosis lineages in China[J]. SCIENCE CHINA-LIFE SCIENCES,2018,61(6):651-659.
APA Chen, Haixia.,He, Li.,Cai, Chao.,Liu, Jingyi.,Jia, Junnan.,...&Li, Weimin.(2018).Characteristics of distribution of Mycobacterium tuberculosis lineages in China.SCIENCE CHINA-LIFE SCIENCES,61(6),651-659.
MLA Chen, Haixia,et al."Characteristics of distribution of Mycobacterium tuberculosis lineages in China".SCIENCE CHINA-LIFE SCIENCES 61.6(2018):651-659.

入库方式： OAI收割

来源：数学与系统科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。