An effective sequence-alignment-free superpositioning of pairwise or multiple structures with missing data
文献类型：期刊论文
| 作者 | Lu,Jianbo1,2; Xu,Guoliang3; Zhang,Shihua3 ; Lu,Benzhuo3
|
| 刊名 | Algorithms for Molecular Biology
 |
| 出版日期 | 2016-06-21 |
| 卷号 | 11期号:1 |
| 关键词 | Superposition Protein structure alignment Iterative closest point |
| ISSN号 | 1748-7188 |
| DOI | 10.1186/s13015-016-0079-3 |
| 英文摘要 | AbstractBackgroundSuperpositioning is an important problem in structural biology. Determining an optimal superposition requires a one-to-one correspondence between the atoms of two proteins structures. However, in practice, some atoms are missing from their original structures. Current superposition implementations address the missing data crudely by ignoring such atoms from their structures.ResultsIn this paper, we propose an effective method for superpositioning pairwise and multiple structures without sequence alignment. It is a two-stage procedure including data reduction and data registration.ConclusionsNumerical experiments demonstrated that our method is effective and efficient. The code package of protein structure superposition method for addressing the cases with missing data is implemented by MATLAB, and it is freely available from: http://sourceforge.net/projects/pssm123/files/?source=navbar |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S13015-016-0079-3 |
| 出版者 | BioMed Central |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/278]  |
| 专题 | 应用数学研究所 计算数学与科学工程计算研究所 |
| 通讯作者 | Zhang,Shihua; Lu,Benzhuo |
| 作者单位 | 1.National Research Institute for Family Planning; Human Genetics Resource Center 2.Graduate School of Peking Union Medical College 3.Academy of Mathematics and Systems Science, Chinese Academy of Sciences; National Center for Mathematics and Interdisciplinary Sciences |
| 推荐引用方式 GB/T 7714 | Lu,Jianbo,Xu,Guoliang,Zhang,Shihua,et al. An effective sequence-alignment-free superpositioning of pairwise or multiple structures with missing data[J]. Algorithms for Molecular Biology,2016,11(1). |
| APA | Lu,Jianbo,Xu,Guoliang,Zhang,Shihua,&Lu,Benzhuo.(2016).An effective sequence-alignment-free superpositioning of pairwise or multiple structures with missing data.Algorithms for Molecular Biology,11(1). |
| MLA | Lu,Jianbo,et al."An effective sequence-alignment-free superpositioning of pairwise or multiple structures with missing data".Algorithms for Molecular Biology 11.1(2016). |
入库方式： OAI收割
来源：数学与系统科学研究院
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