The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events
文献类型：期刊论文
| 作者 | Jin, Guangxu3; Zhou, Xiaobo1; Wang, Honghui5; Zhao, Hong; Cui, Kemi; Zhang, Xiang-Sun3 ; Chen, Luonan6; Hazen, Stanley L.7; Li, King4; Wong, Stephen T. C.
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| 刊名 | JOURNAL OF PROTEOME RESEARCH
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| 出版日期 | 2008-09-01 |
| 卷号 | 7期号:9页码:4013-4021 |
| 关键词 | proteomics mass spectrometry MACE network biomarker cross validation systems biology |
| ISSN号 | 1535-3893 |
| DOI | 10.1021/pr8002886 |
| 英文摘要 | The mass spectrometry (MS) technology in clinical proteomics is very promising for discovery of new biomarkers for diseases management. To overcome the obstacles of data noises in MS analysis, we proposed a new approach of knowledge-integrated biomarker discovery using data from Major Adverse Cardiac Events (MACE) patients. We first built up a cardiovascular-related network based on protein information coming from protein annotations in Uniprot, protein-protein interaction (PPI), and signal transduction database. Distinct from the previous machine learning methods in MS data processing, we then used statistical methods to discover biomarkers in cardiovascular-related network. Through the tradeoff between known protein information and data noises in mass spectrometry data, we finally could firmly identify those high-confident biomarkers. Most importantly, aided by protein-protein interaction network, that is, cardiovascular-related network, we proposed a new type of biomarkers, that is, network biomarkers, composed of a set of proteins and the interactions among them. The candidate network biomarkers can classify the two groups of patients more accurately than current single ones without consideration of biological molecular interaction. |
| 资助项目 | Methodist Research Institute, Cornell University ; The Methodist Hospital ; NIH[R01LM08696] ; NIH[R01LM009161] ; NIH[R01AG028928] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000259015500036 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/5317]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Zhou, Xiaobo |
| 作者单位 | 1.Methodist Hosp, Inst Res, Ctr Biotechnol & Informat, Houston, TX 77030 USA 2.Cornell Univ, Houston, TX 77030 USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 4.Methodist Hosp, Dept Radiol, Houston, TX 77030 USA 5.Natl Inst Hlth, Ctr Clin, Bethesda, MD 20892 USA 6.Osaka Sangyo Univ, Dept Elect Engn, Osaka 5748530, Japan 7.CCF, Ctr Cardiovasc Diagnost & Prevent, Cleveland, OH 44195 USA |
| 推荐引用方式 GB/T 7714 | Jin, Guangxu,Zhou, Xiaobo,Wang, Honghui,et al. The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events[J]. JOURNAL OF PROTEOME RESEARCH,2008,7(9):4013-4021. |
| APA | Jin, Guangxu.,Zhou, Xiaobo.,Wang, Honghui.,Zhao, Hong.,Cui, Kemi.,...&Wong, Stephen T. C..(2008).The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events.JOURNAL OF PROTEOME RESEARCH,7(9),4013-4021. |
| MLA | Jin, Guangxu,et al."The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events".JOURNAL OF PROTEOME RESEARCH 7.9(2008):4013-4021. |
入库方式： OAI收割
来源：数学与系统科学研究院
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