中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 数学与系统科学研究院
  3. 中国科学院数学与系统科学研究院
  4. 应用数学研究所
Bridging protein local structures and protein functions

文献类型：期刊论文

作者Liu, Zhi-Ping2; Wu, Ling-Yun2; Wang, Yong2; Zhang, Xiang-Sun2; Chen, Luonan1
刊名AMINO ACIDS
出版日期2008-10-01
卷号35期号:3页码:627-650
关键词functional genomics functional motifs local structures protein function prediction
ISSN号0939-4451
DOI10.1007/s00726-008-0088-8
英文摘要One of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review, we summarize the repertoire of methods currently being applied and report recent progress in the field of in silico annotation of protein function based on the accumulation of vast amounts of sequence and structure data. In particular, we emphasize the newly developed structure-based methods, which are able to identify locally structural motifs and reveal their relationship with protein functions. These methods include computational tools to identify the structural motifs and reveal the strong relationship between these pre-computed local structures and protein functions. We also discuss remaining problems and possible directions for this exciting and challenging area.
资助项目National Natural Science Foundation of China (NSFC)[10631070] ; National Natural Science Foundation of China (NSFC)[60503004] ; Ministry of Science and Technology, China[5039052006CB] ; NSFC-JSPS[10711140116]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000258833500013
出版者SPRINGER
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/6317]  
专题应用数学研究所
通讯作者Chen, Luonan
作者单位1.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,et al. Bridging protein local structures and protein functions[J]. AMINO ACIDS,2008,35(3):627-650.
APA Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,Zhang, Xiang-Sun,&Chen, Luonan.(2008).Bridging protein local structures and protein functions.AMINO ACIDS,35(3),627-650.
MLA Liu, Zhi-Ping,et al."Bridging protein local structures and protein functions".AMINO ACIDS 35.3(2008):627-650.

入库方式： OAI收割

来源：数学与系统科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。