Predicting DNA- and RNA-binding proteins from sequences with kernel methods
文献类型:期刊论文
作者 | Shao, Xiaojian1; Tian, Yingjie2; Wu, Lingyun3![]() ![]() |
刊名 | JOURNAL OF THEORETICAL BIOLOGY
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出版日期 | 2009-05-21 |
卷号 | 258期号:2页码:289-293 |
关键词 | Bioinformatics Protein function Conjoint triad Nucleic-acid-binding protein Support vector machine |
ISSN号 | 0022-5193 |
DOI | 10.1016/j.jtbi.2009.01.024 |
英文摘要 | In this paper, Support vector machines (SVMs) are applied to predict the nucleic-acid-binding proteins. We constructed two classifiers to differentiate DNA/RNA-binding proteins from non-nucleic-acid-binding proteins by using a conjoint triad feature which extract information directly from amino acids sequence of protein. Both self-consistency and jackknife tests show promising results oil the protein datasets in which the sequences identity is less than 25%. In the self-consistency test, the predictive accuracy is 90.37% for DNA-binding proteins and 89.70% for RNA-binding proteins. In the jackknife test, the predictive accuracies are 78.93% and 76.75%, respectively. Comparison results Show that Our method is very competitive by Outperforming other previously published sequence-based prediction methods. (C) 2009 Elsevier Ltd. All rights reserved. |
资助项目 | National Natural Science Foundation of China[10631070] ; National Natural Science Foundation of China[10601064] |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology |
语种 | 英语 |
WOS记录号 | WOS:000265801600013 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/7736] ![]() |
专题 | 应用数学研究所 |
通讯作者 | Deng, Naiyang |
作者单位 | 1.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Res Ctr Fictitious Econ & Data Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Shao, Xiaojian,Tian, Yingjie,Wu, Lingyun,et al. Predicting DNA- and RNA-binding proteins from sequences with kernel methods[J]. JOURNAL OF THEORETICAL BIOLOGY,2009,258(2):289-293. |
APA | Shao, Xiaojian,Tian, Yingjie,Wu, Lingyun,Wang, Yong,Jing, Ling,&Deng, Naiyang.(2009).Predicting DNA- and RNA-binding proteins from sequences with kernel methods.JOURNAL OF THEORETICAL BIOLOGY,258(2),289-293. |
MLA | Shao, Xiaojian,et al."Predicting DNA- and RNA-binding proteins from sequences with kernel methods".JOURNAL OF THEORETICAL BIOLOGY 258.2(2009):289-293. |
入库方式: OAI收割
来源:数学与系统科学研究院
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