中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A hybrid graph-theoretic method for mining overlapping functional modules in large sparse protein interaction networks

文献类型:期刊论文

作者Zhang, Shihua1,2; Liu, Hong-Wei3; Ning, Xue-Mei4; Zhang, Xiang-Sun1
刊名INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS
出版日期2009
卷号3期号:1页码:68-84
关键词PPI protein-protein interaction network network clustering LGT line graph transformation protein complexes functional modules data mining bioinformatics
ISSN号1748-5673
英文摘要Modular architecture, which encompasses groups of genes/proteins involved in elementary biological functional units, is a basic form of the organisation of interacting proteins. Here, we propose a method that combines the Line Graph Transformation (LGT) and clique percolation-clustering algorithm to detect network modules, which may overlap each other in large sparse PPI networks. The resulting modules by the present method show a high coverage among yeast, fly, and worm PPI networks, respectively. Our analysis of the yeast PPI network suggests that most of these modules have well-biological significance in context of protein localisation, function annotation, and protein complexes.
WOS研究方向Mathematical & Computational Biology
语种英语
WOS记录号WOS:000265541400006
出版者INDERSCIENCE ENTERPRISES LTD
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/8183]  
专题应用数学研究所
通讯作者Zhang, Shihua
作者单位1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Beijing Wuzi Univ, Beijing 101149, Peoples R China
4.Beijing Forestry Univ, Coll Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Shihua,Liu, Hong-Wei,Ning, Xue-Mei,et al. A hybrid graph-theoretic method for mining overlapping functional modules in large sparse protein interaction networks[J]. INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS,2009,3(1):68-84.
APA Zhang, Shihua,Liu, Hong-Wei,Ning, Xue-Mei,&Zhang, Xiang-Sun.(2009).A hybrid graph-theoretic method for mining overlapping functional modules in large sparse protein interaction networks.INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS,3(1),68-84.
MLA Zhang, Shihua,et al."A hybrid graph-theoretic method for mining overlapping functional modules in large sparse protein interaction networks".INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS 3.1(2009):68-84.

入库方式: OAI收割

来源:数学与系统科学研究院

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