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Lysine acetylation sites prediction using an ensemble of support vector machine classifiers

文献类型：期刊论文

作者Xu, Yan1,2; Wang, Xiao-Bo1; Ding, Jun2; Wu, Ling-Yun3; Deng, Nai-Yang1
刊名JOURNAL OF THEORETICAL BIOLOGY
出版日期2010-05-07
卷号264期号:1页码:130-135
关键词Bioinformatics Acetylated proteins Ensemble SVM PWMs EnsemblePail
ISSN号0022-5193
DOI10.1016/j.jtbi.2010.01.013
英文摘要Lysine acetylation is an essentially reversible and high regulated post-translational modification which regulates diverse protein properties. Experimental identification of acetylation sites is laborious and expensive. Hence, there is significant interest in the development of computational methods for reliable prediction of acetylation sites from amino acid sequences. In this paper we use an ensemble of support vector machine classifiers to perform this work. The experimentally determined acetylation lysine sites are extracted from Swiss-Prot database and scientific literatures. Experiment results show that an ensemble of support vector machine classifiers outperforms single support vector machine classifier and other computational methods such as PAIL and LysAcet on the problem of predicting acetylation lysine sites. The resulting method has been implemented in EnsemblePail, a web server for lysine acetylation sites prediction available at http://www.aporc.org/EnsemblePail/. (C) 2010 Elsevier Ltd. All rights reserved.
资助项目Key Project of the National Natural Science Foundation of China[10631070] ; National Natural Science Foundation of China[10971223]
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
语种英语
WOS记录号WOS:000275966500015
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/10439]  
专题应用数学研究所
通讯作者Deng, Nai-Yang
作者单位1.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
2.Univ Sci & Technol Beijing, Dept Math, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yan,Wang, Xiao-Bo,Ding, Jun,et al. Lysine acetylation sites prediction using an ensemble of support vector machine classifiers[J]. JOURNAL OF THEORETICAL BIOLOGY,2010,264(1):130-135.
APA Xu, Yan,Wang, Xiao-Bo,Ding, Jun,Wu, Ling-Yun,&Deng, Nai-Yang.(2010).Lysine acetylation sites prediction using an ensemble of support vector machine classifiers.JOURNAL OF THEORETICAL BIOLOGY,264(1),130-135.
MLA Xu, Yan,et al."Lysine acetylation sites prediction using an ensemble of support vector machine classifiers".JOURNAL OF THEORETICAL BIOLOGY 264.1(2010):130-135.

入库方式： OAI收割

来源：数学与系统科学研究院

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