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Marginal regression models with time-varying coefficients for recurrent event data

文献类型：期刊论文

作者Sun, Liuquan2; Zhou, Xian1; Guo, Shaojun2
刊名STATISTICS IN MEDICINE
出版日期2011-08-15
卷号30期号:18页码:2265-2277
关键词recurrent event data cumulative regression function marginal rates model model checking semiparametric model time-varying coefficients
ISSN号0277-6715
DOI10.1002/sim.4260
英文摘要Recurrent event data arise frequently from medical research. Examples include repeated infections, recurrence of tumors, relapse of leukemia, repeated hospitalizations, recurrence of symptoms of a disease, and so on. In the analysis of recurrent event data, the proportional rates model assumes that the regression coefficients are time invariant. In reality, however, these parameters may vary over time, and the temporal covariate effects on the event process are of great interest. In this article, we formulate a class of semiparametric marginal rates models, which incorporate a mixture of time-varying and time-independent parameters, to analyze recurrent event data. For statistical inference on model parameters, an estimation procedure is developed and asymptotic properties of the proposed estimators are established. In addition, we develop tests for investigating whether or not covariate effects vary with time. The finite-sample behaviors of the proposed methods are examined in simulation studies. An example of application of the proposed methodology is illustrated on a set of data from a clinic study on chronic granulomatous disease. Copyright (C) 2011 John Wiley & Sons, Ltd.
资助项目Macquarie University ; National Natural Science Foundation of China[10731010] ; National Natural Science Foundation of China[10971015] ; National Natural Science Foundation of China[10721101] ; National Basic Research Program of China (973 Program)[2007CB814902] ; Key Laboratory of RCSDS, CAS[2008DP173182]
WOS研究方向Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
语种英语
WOS记录号WOS:000292740100005
出版者WILEY-BLACKWELL
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/13011]  
专题应用数学研究所
通讯作者Zhou, Xian
作者单位1.Macquarie Univ, Dept Actuarial Studies, Sydney, NSW 2109, Australia
2.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Liuquan,Zhou, Xian,Guo, Shaojun. Marginal regression models with time-varying coefficients for recurrent event data[J]. STATISTICS IN MEDICINE,2011,30(18):2265-2277.
APA Sun, Liuquan,Zhou, Xian,&Guo, Shaojun.(2011).Marginal regression models with time-varying coefficients for recurrent event data.STATISTICS IN MEDICINE,30(18),2265-2277.
MLA Sun, Liuquan,et al."Marginal regression models with time-varying coefficients for recurrent event data".STATISTICS IN MEDICINE 30.18(2011):2265-2277.

入库方式： OAI收割

来源：数学与系统科学研究院

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