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iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity

文献类型：期刊论文

作者Xu, Yan1; Ding, Ya-Xin1; Ding, Jun1; Lei, Ya-Hui1; Wu, Ling-Yun2; Deng, Nai-Yang3
刊名SCIENTIFIC REPORTS
出版日期2015-06-18
卷号5页码:6
ISSN号2045-2322
DOI10.1038/srep10184
英文摘要Lysine succinylation in protein is one type of post-translational modifications (PTMs). Succinylation is associated with some diseases and succinylated sites data just has been found in recent years in experiments. It is highly desired to develop computational methods to identify the candidate proteins and their sites. In view of this, a new predictor called iSuc-PseAAC was proposed by incorporating the peptide position-specific propensity into the general form of pseudo amino acid composition. The accuracy is 79.94%, sensitivity 51.07%, specificity 89.42% and MCC 0.431 in leave-one-out cross validation with support vector machine algorithm. It demonstrated by rigorous leaveone- out on stringent benchmark dataset that the new predictor is quite promising and may become a useful high throughput tool in this area. Meanwhile a user-friendly web-server for iSuc-PseAAC is accessible at http://app.aporc.org/iSuc-PseAAC/. Users can easily obtain their desired results without the need to understand the complicated mathematical equations presented in this paper just for its integrity.
资助项目Natural Science Foundation of China[11301024] ; Natural Science Foundation of China[11371365] ; Natural Science Foundation of China[31201002] ; Natural Science Foundation of China[11131009]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000356523700001
出版者NATURE PUBLISHING GROUP
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/20055]  
专题应用数学研究所
通讯作者Xu, Yan
作者单位1.Univ Sci & Technol Beijing, Dept Informat & Comp Sci, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China
3.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yan,Ding, Ya-Xin,Ding, Jun,et al. iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity[J]. SCIENTIFIC REPORTS,2015,5:6.
APA Xu, Yan,Ding, Ya-Xin,Ding, Jun,Lei, Ya-Hui,Wu, Ling-Yun,&Deng, Nai-Yang.(2015).iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity.SCIENTIFIC REPORTS,5,6.
MLA Xu, Yan,et al."iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity".SCIENTIFIC REPORTS 5(2015):6.

入库方式： OAI收割

来源：数学与系统科学研究院

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