Identifying joint biomarker panel from multiple level dataset by an optimization model
文献类型：期刊论文
| 作者 | Zou, Meng1; Zhang, Peng-Jun2; Chen, Luonan3; Tian, Ya-Ping2; Wang, Yong1
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| 刊名 | BIOMARKERS IN MEDICINE
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 10期号:6页码:567-575 |
| 关键词 | group lasso optimization joint biomarker panel multiple level dataset |
| ISSN号 | 1752-0363 |
| DOI | 10.2217/bmm-2015-0022 |
| 英文摘要 | Aim: Joint biomarker panel takes advantage of coherence across multiple level datasets and holds the promise to improve disease diagnosis accuracy. Methods: We collected 101 colorectal cancer and 95 benign samples, measured the molecular concentrations by serum assays and mass spectra, and developed LPGLO (Linear Programming based on Group Lasso Optimization) to identify the joint biomarker panel. Results: A joint biomarker panel, with ten serum biomarkers and six mass spectra peaks, achieves LOOCV accuracy 0.8724, which is better than the optimal panels identified from separate datasets (LOOCV = 0.7551 for mass spectra only or 0.8265 for serum assay only) and the simply merged dataset (LOOCV = 0.8622). Conclusion: LPGLO is useful to identify joint biomarker panel to help tumor diagnosis. |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13040700] ; National Natural Science Foundation of China (NSFC)[11422108] ; National Natural Science Foundation of China (NSFC)[11131009] ; NSFC[61134013] ; NSFC[91439103] ; NSFC[81071413] ; Knowledge Innovation Program of the Chinese Academy of Sciences (CAS)[KSCX2-EW-R-01] ; National High Technology Research and Development Program[2011AA02A111] ; China Postdoctoral Science Special Foundation[2014T70963] ; China Postdoctoral Science Foundation[2013M532110] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000379503100003 |
| 出版者 | FUTURE MEDICINE LTD |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/23111]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Chen, Luonan; Tian, Ya-Ping; Wang, Yong |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Core Lab Translat Med, State Key Lab Kidney Dis, Beijing 100853, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Key Lab Syst Biol, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Meng,Zhang, Peng-Jun,Chen, Luonan,et al. Identifying joint biomarker panel from multiple level dataset by an optimization model[J]. BIOMARKERS IN MEDICINE,2016,10(6):567-575. |
| APA | Zou, Meng,Zhang, Peng-Jun,Chen, Luonan,Tian, Ya-Ping,&Wang, Yong.(2016).Identifying joint biomarker panel from multiple level dataset by an optimization model.BIOMARKERS IN MEDICINE,10(6),567-575. |
| MLA | Zou, Meng,et al."Identifying joint biomarker panel from multiple level dataset by an optimization model".BIOMARKERS IN MEDICINE 10.6(2016):567-575. |
入库方式： OAI收割
来源：数学与系统科学研究院
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