IRWRLDA: improved random walk with restart for lncRNA-disease association prediction
文献类型：期刊论文
| 作者 | Chen, Xing1; You, Zhu-Hong2; Yan, Gui-Ying3,4 ; Gong, Dun-Wei1
|
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2016-09-06 |
| 卷号 | 7期号:36页码:57919-57931 |
| 关键词 | lncRNAs disease cancer random walk with restart |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.11141 |
| 英文摘要 | In recent years, accumulating evidences have shown that the dysregulations of lncRNAs are associated with a wide range of human diseases. It is necessary and feasible to analyze known lncRNA-disease associations, predict potential lncRNA-disease associations, and provide the most possible lncRNA-disease pairs for experimental validation. Considering the limitations of traditional Random Walk with Restart (RWR), the model of Improved Random Walk with Restart for LncRNA-Disease Association prediction (IRWRLDA) was developed to predict novel lncRNA-disease associations by integrating known lncRNA-disease associations, disease semantic similarity, and various lncRNA similarity measures. The novelty of IRWRLDA lies in the incorporation of lncRNA expression similarity and disease semantic similarity to set the initial probability vector of the RWR. Therefore, IRWRLDA could be applied to diseases without any known related lncRNAs. IRWRLDA significantly improved previous classical models with reliable AUCs of 0.7242 and 0.7872 in two known lncRNA-disease association datasets downloaded from the lncRNA-Disease database, respectively. Further case studies of colon cancer and leukemia were implemented for IRWRLDA and 60% of lncRNAs in the top 10 prediction lists have been confirmed by recent experimental reports. |
| 资助项目 | National Natural Science Foundation of China[11301517] ; National Natural Science Foundation of China[61572506] ; National Natural Science Foundation of China[11371355] |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000387153200036 |
| 出版者 | IMPACT JOURNALS LLC |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/24065]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Chen, Xing; You, Zhu-Hong |
| 作者单位 | 1.China Univ Min & Technol, Sch Informat & Elect Engn, Xuzhou 221116, Peoples R China 2.China Univ Min & Technol, Sch Comp Sci & Technol, Xuzhou 221116, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xing,You, Zhu-Hong,Yan, Gui-Ying,et al. IRWRLDA: improved random walk with restart for lncRNA-disease association prediction[J]. ONCOTARGET,2016,7(36):57919-57931. |
| APA | Chen, Xing,You, Zhu-Hong,Yan, Gui-Ying,&Gong, Dun-Wei.(2016).IRWRLDA: improved random walk with restart for lncRNA-disease association prediction.ONCOTARGET,7(36),57919-57931. |
| MLA | Chen, Xing,et al."IRWRLDA: improved random walk with restart for lncRNA-disease association prediction".ONCOTARGET 7.36(2016):57919-57931. |
入库方式： OAI收割
来源：数学与系统科学研究院
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