Integrative cancer genomics: models, algorithms and analysis
文献类型：期刊论文
| 作者 | Chen, Jinyu; Zhang, Shihua
|
| 刊名 | FRONTIERS OF COMPUTER SCIENCE
 |
| 出版日期 | 2017-06-01 |
| 卷号 | 11期号:3页码:392-406 |
| 关键词 | cancer genomics model algorithm data integration bioinformatics computational biology |
| ISSN号 | 2095-2228 |
| DOI | 10.1007/s11704-016-5568-5 |
| 英文摘要 | In the past decade, the remarkable development of high-throughput sequencing technology accelerates the generation of large amount of multiple dimensional data such as genomic, epigenomic, transcriptomic and proteomic data. The comprehensive data make it possible to understand the underlying mechanisms of biology and disease such as cancer systematically. It also provides great challenges for computational cancer genomics due to the complexity, scale and noise of data. In this article, we aim to review the recent developments and progresses of computational models, algorithms and analysis of complex data in cancer genomics. These topics of this paper include the identification of driver mutations, the genetic heterogeneity analysis, genomic markers discovery of drug response, pan-cancer scale analysis and so on. |
| 资助项目 | National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11131009] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science, CAS[2008DP173182] |
| WOS研究方向 | Computer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000402062400003 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/25505]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Zhang, Shihua |
| 作者单位 | Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jinyu,Zhang, Shihua. Integrative cancer genomics: models, algorithms and analysis[J]. FRONTIERS OF COMPUTER SCIENCE,2017,11(3):392-406. |
| APA | Chen, Jinyu,&Zhang, Shihua.(2017).Integrative cancer genomics: models, algorithms and analysis.FRONTIERS OF COMPUTER SCIENCE,11(3),392-406. |
| MLA | Chen, Jinyu,et al."Integrative cancer genomics: models, algorithms and analysis".FRONTIERS OF COMPUTER SCIENCE 11.3(2017):392-406. |
入库方式： OAI收割
来源：数学与系统科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。