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Mark-specific additive hazards regression with continuous marks

文献类型：期刊论文

作者Han, Dongxiao1; Sun, Liuquan1; Sun, Yanqing2; Qi, Li3
刊名LIFETIME DATA ANALYSIS
出版日期2017-07-01
卷号23期号:3页码:467-494
关键词Additive hazards model Competing risks Confidence bands and tests Continuous mark HIV vaccine trial Mark-specific vaccine effects Survival data
ISSN号1380-7870
DOI10.1007/s10985-016-9369-9
英文摘要For survival data, mark variables are only observed at uncensored failure times, and it is of interest to investigate whether there is any relationship between the failure time and the mark variable. The additive hazards model, focusing on hazard differences rather than hazard ratios, has been widely used in practice. In this article, we propose a mark-specific additive hazards model in which both the regression coefficient functions and the baseline hazard function depend nonparametrically on a continuous mark. An estimating equation approach is developed to estimate the regression functions, and the asymptotic properties of the resulting estimators are established. In addition, some formal hypothesis tests are constructed for various hypotheses concerning the mark-specific treatment effects. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a data set from the first HIV vaccine efficacy trial is provided.
资助项目National Natural Science Foundation of China[11231010] ; National Natural Science Foundation of China[11171330] ; Key Laboratory of RCSDS, CAS[2008DP173182] ; BCMIIS ; National Institutes of Health NIAID[R37 AI054165] ; National Science Foundation[DMS-1208978] ; National Science Foundation[DMS-1513072]
WOS研究方向Mathematics
语种英语
WOS记录号WOS:000403359100007
出版者SPRINGER
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/25645]  
专题应用数学研究所
通讯作者Sun, Liuquan
作者单位1.Chinese Acad Sci, Inst Appl Math, Beijing 100190, Peoples R China
2.Univ North Carolina Charlotte, Dept Math & Stat, Charlotte, NC 28223 USA
3.Sanofi, Biostat & Programming, Bridgewater, NJ 08807 USA
推荐引用方式
GB/T 7714		 Han, Dongxiao,Sun, Liuquan,Sun, Yanqing,et al. Mark-specific additive hazards regression with continuous marks[J]. LIFETIME DATA ANALYSIS,2017,23(3):467-494.
APA Han, Dongxiao,Sun, Liuquan,Sun, Yanqing,&Qi, Li.(2017).Mark-specific additive hazards regression with continuous marks.LIFETIME DATA ANALYSIS,23(3),467-494.
MLA Han, Dongxiao,et al."Mark-specific additive hazards regression with continuous marks".LIFETIME DATA ANALYSIS 23.3(2017):467-494.

入库方式： OAI收割

来源：数学与系统科学研究院

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