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Gene co-opening network deciphers gene functional relationships

文献类型：期刊论文

作者Li, Wenran1,2; Wang, Meng1,2; Sun, Jinghao1,2; Wang, Yong3; Jiang, Rui1,2
刊名MOLECULAR BIOSYSTEMS
出版日期2017-11-01
卷号13期号:11页码:2428-2439
ISSN号1742-206X
DOI10.1039/c7mb00430c
英文摘要Genome sequencing technology has generated a vast amount of genomic and epigenomic data, and has provided us a great opportunity to study gene functions on a global scale from an epigenomic view. In the last decade, network-based studies, such as those based on PPI networks and co-expression networks, have shown good performance in capturing functional relationships between genes. However, the functions of a gene and the mechanism of interaction of genes with each other to elucidate their functions are still not entirely clear. Here, we construct a gene co-opening network based on chromatin accessibility of genes. We show that genes related to a specific biological process or the same disease tend to be clustered in the co-opening network. This understanding allows us to detect functional clusters from the network and to predict new functions for genes. We further apply the network to prioritize disease genes for Psoriasis, and demonstrate the power of the joint analysis of the co-opening network and GWAS data in identifying disease genes. Taken together, the co-opening network provides a new viewpoint for the elucidation of gene associations and the interpretation of disease mechanisms.
资助项目National Natural Science Foundation of China[61721003] ; National Natural Science Foundation of China[61573207] ; National Natural Science Foundation of China[61671444] ; National Natural Science Foundation of China[11422108] ; National Natural Science Foundation of China[61175002] ; State Key Laboratory of Cardiovascular Disease[2016-kf04]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000413732100024
出版者ROYAL SOC CHEMISTRY
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/29140]  
专题应用数学研究所
通讯作者Wang, Yong; Jiang, Rui
作者单位1.Tsinghua Univ, MOE, Key Lab Bioinformat, Bioinformat Div, Beijing 100084, Peoples R China
2.Tsinghua Univ, Dept Automat, Ctr Synthet & Syst Biol, TNLIST, Beijing 100084, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, CEMS, NCMIS,MADIS, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714		 Li, Wenran,Wang, Meng,Sun, Jinghao,et al. Gene co-opening network deciphers gene functional relationships[J]. MOLECULAR BIOSYSTEMS,2017,13(11):2428-2439.
APA Li, Wenran,Wang, Meng,Sun, Jinghao,Wang, Yong,&Jiang, Rui.(2017).Gene co-opening network deciphers gene functional relationships.MOLECULAR BIOSYSTEMS,13(11),2428-2439.
MLA Li, Wenran,et al."Gene co-opening network deciphers gene functional relationships".MOLECULAR BIOSYSTEMS 13.11(2017):2428-2439.

入库方式： OAI收割

来源：数学与系统科学研究院

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