Large-scale determination and characterization of cell type-specific regulatory elements in the human genome
文献类型：期刊论文
| 作者 | Wang, Can1,2; Zhang, Shihua1,2; Zhang Shihua
|
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 9期号:6页码:463-476 |
| 关键词 | epigenomics histone modification cell type-specific regulatory elements bioinformatics |
| ISSN号 | 1674-2788 |
| DOI | 10.1093/jmcb/mjx058 |
| 英文摘要 | Histone modifications have been widely elucidated to play vital roles in gene regulation and cell identity. The Roadmap Epigenomics Consortium generated a reference catalog of several key histone modifications across >100s of human cell types and tissues. Decoding these epigenomes into functional regulatory elements is a challenging task in computational biology. To this end, we adopted a differential chromatin modification analysis framework to comprehensively determine and characterize cell type-specific regulatory elements (CSREs) and their histone modification codes in the human epigenomes of five histone modifications across 127 tissues or cell types. The CSREs show significant relevance with cell type-specific biological functions and diseases and cell identity. Clustering of CSREs with their specificity signals reveals distinct histone codes, demonstrating the diversity of functional roles of CSREs within the same cell or tissue. Last but not least, dynamics of CSREs from close cell types or tissues can give a detailed view of developmental processes such as normal tissue development and cancer occurrence. |
| 资助项目 | National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11661141019] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; CAS Frontier Science Research Key Project for Top Young Scientist[QYZDB-SSW-SYS008] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11661141019] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; CAS Frontier Science Research Key Project for Top Young Scientist[QYZDB-SSW-SYS008] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000425284600004 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/29661]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Zhang, Shihua |
| 作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, RCSDS, NCMIS,CEMS, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Can,Zhang, Shihua,Zhang Shihua. Large-scale determination and characterization of cell type-specific regulatory elements in the human genome[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2017,9(6):463-476. |
| APA | Wang, Can,Zhang, Shihua,&Zhang Shihua.(2017).Large-scale determination and characterization of cell type-specific regulatory elements in the human genome.JOURNAL OF MOLECULAR CELL BIOLOGY,9(6),463-476. |
| MLA | Wang, Can,et al."Large-scale determination and characterization of cell type-specific regulatory elements in the human genome".JOURNAL OF MOLECULAR CELL BIOLOGY 9.6(2017):463-476. |
入库方式： OAI收割
来源：数学与系统科学研究院
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