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The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms

文献类型：期刊论文

作者Zhang, Junhua1,2; Zhang, Shihua1,2
刊名IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
出版日期2018-05-01
卷号15期号:3页码:988-998
关键词Bioinformatics cancer genomics driver gene driver pathway mutual exclusivity co-occurring mutation
ISSN号1545-5963
DOI10.1109/TCBB.2016.2640963
英文摘要The pathogenesis of cancer in human is still poorly understood. With the rapid development of high-throughput sequencing technologies, huge volumes of cancer genomics data have been generated. Deciphering that data poses great opportunities and challenges to computational biologists. One of such key challenges is to distinguish driver mutations, genes as well as pathways from passenger ones. Mutual exclusivity of gene mutations (each patient has no more than one mutation in the gene set) has been observed in various cancer types and thus has been used as an important property of a driver gene set or pathway. In this article, we aim to review the recent development of computational models and algorithms for discovering driver pathways or modules in cancer with the focus on mutual exclusivity-based ones.
资助项目National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11661141019] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; CAS Frontier Science Research Key Project for Top Young Scientist[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science, CAS[2008DP173182]
WOS研究方向Biochemistry & Molecular Biology ; Computer Science ; Mathematics
语种英语
WOS记录号WOS:000434295100028
出版者IEEE COMPUTER SOC
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/30411]  
专题应用数学研究所
通讯作者Zhang, Junhua
作者单位1.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Junhua,Zhang, Shihua. The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms[J]. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,2018,15(3):988-998.
APA Zhang, Junhua,&Zhang, Shihua.(2018).The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms.IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,15(3),988-998.
MLA Zhang, Junhua,et al."The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms".IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS 15.3(2018):988-998.

入库方式： OAI收割

来源：数学与系统科学研究院

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