Improved correction for population stratification in genome-wide association studies by identifying hidden population structures
文献类型：期刊论文
| 作者 | Li, Qizhai1,2 ; Yu, Kai1
|
| 刊名 | GENETIC EPIDEMIOLOGY
 |
| 出版日期 | 2008-04-01 |
| 卷号 | 32期号:3页码:215-226 |
| 关键词 | population stratification genome-wide association studies likelihood ratio test multidimensional scaling |
| ISSN号 | 0741-0395 |
| DOI | 10.1002/gepi.20296 |
| 英文摘要 | Hidden population substructure can cause population stratification and lead to false-positive findings in population-based genome-wide association (GWA) studies. Given a large panel of markers scanned in a GWA study, it becomes increasingly feasible to uncover the hidden population substructure within the study sample based on measured genotypes across the genome. Recognizing that population substructure can be displayed as clustered and/or continuous patterns of genetic variation, we propose a method that aims at the detection and correction of the confounding effect resulting from both patterns of population substructure. The proposed method is an extension of the EIGENSTRAT method (Price et al. [2006] Nat Genet 38:904-909). This approach is computationally feasible and easily applied to large-scale GWA studies. We show through simulation studies that, compared with the EIGENSTRAT method, the new method requires a smaller number of markers and yields a more appropriate correction for population stratification. |
| WOS研究方向 | Genetics & Heredity ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000254690500003 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/5487]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Yu, Kai |
| 作者单位 | 1.NCI, NIH, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qizhai,Yu, Kai. Improved correction for population stratification in genome-wide association studies by identifying hidden population structures[J]. GENETIC EPIDEMIOLOGY,2008,32(3):215-226. |
| APA | Li, Qizhai,&Yu, Kai.(2008).Improved correction for population stratification in genome-wide association studies by identifying hidden population structures.GENETIC EPIDEMIOLOGY,32(3),215-226. |
| MLA | Li, Qizhai,et al."Improved correction for population stratification in genome-wide association studies by identifying hidden population structures".GENETIC EPIDEMIOLOGY 32.3(2008):215-226. |
入库方式： OAI收割
来源：数学与系统科学研究院
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