Joint modeling of time series measures and recurrent events and analysis of the effects of air quality on respiratory symptoms
文献类型：期刊论文
| 作者 | Zhang, Heping1,2; Ye, Yuanqing; Diggle, Peter3,4; Shi, Jian5
|
| 刊名 | JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 103期号:481页码:48-60 |
| 关键词 | censored data joint analysis longitudinal data recurrent event |
| ISSN号 | 0162-1459 |
| DOI | 10.1198/016214507000000185 |
| 英文摘要 | Exposure to ambient pollutants at concentrations above defined standards is a risk factor for respiratory symptoms, especially in sensitive children. Many studies have been undertaken to monitor air quality and to assess its association with respiratory symptoms. We propose a joint mixed-effects regression model of time series measures and recurrent events to analyze the air quality and respiratory symptom data from the Yale Mothers and Infants Health Study. Three mothers' symptoms (runny nose, cough, and sore throat) and three infants' symptoms (runny nose, cough, and general sickness) were investigated. To alleviate the computational complexity, a two-stage maximum likelihood-based estimation procedure is introduced to estimate the parameters, and simulation studies are conducted to assess the validity of this estimation procedure. Our analysis reveals differences in the etiology of respiratory symptoms between mothers and infants. Most notably, coarse particles of mass between 2.5 and 10 mu in diameter increased the risks of mothers' runny nose and cough symptoms but had no significant effect on any of the three infants' symptoms. The sulfate level was negatively associated with the risk of infants' runny nose and cough symptoms but had no significant effect on any of the three mothers' symptoms. High level of humidity is negatively associated with the mothers' cough incidence but had no significant association with any of the three infants' symptoms. Such differences reveal not only the sensitivity of the mothers and infants to the air quality, but also call for further understanding of the differences. It is possible that actions taken to overcome humidity by mothers may inadvertently affect their infants. |
| WOS研究方向 | Mathematics |
| 语种 | 英语 |
| WOS记录号 | WOS:000254311500013 |
| 出版者 | AMER STATISTICAL ASSOC |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/6526]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Zhang, Heping |
| 作者单位 | 1.Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA 2.Jiangxi Normal Univ, Jiangxi, Peoples R China 3.Univ Lancaster, Dept Med, Lancaster LA1 4YF, England 4.Johns Hopkins Univ, Sch Publ Hlth, Dept Biostat, Baltimore, MD 21205 USA 5.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Heping,Ye, Yuanqing,Diggle, Peter,et al. Joint modeling of time series measures and recurrent events and analysis of the effects of air quality on respiratory symptoms[J]. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION,2008,103(481):48-60. |
| APA | Zhang, Heping,Ye, Yuanqing,Diggle, Peter,&Shi, Jian.(2008).Joint modeling of time series measures and recurrent events and analysis of the effects of air quality on respiratory symptoms.JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION,103(481),48-60. |
| MLA | Zhang, Heping,et al."Joint modeling of time series measures and recurrent events and analysis of the effects of air quality on respiratory symptoms".JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION 103.481(2008):48-60. |
入库方式： OAI收割
来源：数学与系统科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。