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A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma
文献类型：期刊论文
| 作者 | Landi, Maria Teresa1; Chatterjee, Nilanjan1; Yu, Kai1; Goldin, Lynn R.1; Goldstein, Alisa M.1; Rotunno, Melissa1; Mirabello, Lisa1; Jacobs, Kevin1; Wheeler, William2; Yeager, Meredith1 |
| 刊名 | AMERICAN JOURNAL OF HUMAN GENETICS
 |
| 出版日期 | 2009-11-13 |
| 卷号 | 85期号:5页码:679-691 |
| ISSN号 | 0002-9297 |
| DOI | 10.1016/j.ajhg.2009.09.012 |
| 英文摘要 | Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of king cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four Studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SQ. In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13-1.33, p = 3.02 x 10(-7)), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17-1.31, p = 3.74 x 10(-14) for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma. |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000271916500014 |
| 出版者 | CELL PRESS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/9136]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Landi, Maria Teresa |
| 作者单位 | 1.NCI, Div Canc Epidemiol, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA 2.Informat Management Serv Inc, Rockville, MD 20852 USA 3.SRI Int, Ctr Hlth Sci, Mol Genet program, Menlo Pk, CA 94025 USA 4.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing 100190, Peoples R China 5.Osped Maggiore Policlin Mangiagalli & Regina Elen, Fdn Ist Ricevero & Cura Carattere Sci, Epidemiol Unit, I-20122 Milan, Italy 6.Univ Milan, Dept Occupat & Environm Hlth, I-20122 Milan, Italy 7.Amer Canc Soc Epidemiol & Surveillance Res, Atlanta, GA 30301 USA 8.Univ Minnesota, Hubert H Humphrey Canc Ctr, Minneapolis, MN 55455 USA 9.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00280, Finland 10.Johns Hopkins Univ, Sch Med, Inst Med Genet, Ctr Inherited Dis Res, Baltimore, MD 21224 USA |
| 推荐引用方式 GB/T 7714 | Landi, Maria Teresa,Chatterjee, Nilanjan,Yu, Kai,et al. A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2009,85(5):679-691. |
| APA | Landi, Maria Teresa.,Chatterjee, Nilanjan.,Yu, Kai.,Goldin, Lynn R..,Goldstein, Alisa M..,...&Caporaso, Neil E..(2009).A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.AMERICAN JOURNAL OF HUMAN GENETICS,85(5),679-691. |
| MLA | Landi, Maria Teresa,et al."A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma".AMERICAN JOURNAL OF HUMAN GENETICS 85.5(2009):679-691. |
入库方式： OAI收割
来源：数学与系统科学研究院
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