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Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

文献类型：期刊论文

作者Yue, Wei-Hua1,2; Wang, Hai-Feng3,4; Sun, Liang-Dan5,6,7; Tang, Fu-Lei1,2; Liu, Zhong-Hua8; Zhang, Hong-Xing9,10; Li, Wen-Qiang9,10; Zhang, Yan-Ling1,2; Zhang, Yang1,2; Ma, Cui-Cui11
刊名NATURE GENETICS
出版日期2011-12-01
卷号43期号:12页码:1228-U84
ISSN号1061-4036
DOI10.1038/ng.979
英文摘要To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 x 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 x 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 x 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 x 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 x 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 x 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.
资助项目National High-Tech Research and Development Program of China[2009AA022702] ; National Natural Science Foundation of China[30530290] ; National Natural Science Foundation of China[30870896] ; National Natural Science Foundation of China[81071087] ; National Natural Science Foundation of China[81071088] ; National Basic Research Program of China[2007CB512301] ; National Basic Research Program of China[2011CB707805] ; International Science & Technology Cooperation Program of China[2010DFB30820]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000297931400017
出版者NATURE PUBLISHING GROUP
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/11435]  
专题系统科学研究所
通讯作者Zhang, Dai
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
3.Chinese Natl Human Genome Ctr Shanghai, Shanghai Minist Sci & Technol China, Key Lab Hlth & Dis Genom, Shanghai, Peoples R China
4.Shanghai Jiao Tong Univ, State Key Lab Med Genom, Ruijin Hosp, Shanghai 200030, Peoples R China
5.Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei, Peoples R China
6.Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei, Peoples R China
7.Minist Sci & Technol, State Key Lab Dermatol, Hefei, Peoples R China
8.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China
9.Xinxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Peoples R China
10.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
推荐引用方式
GB/T 7714		 Yue, Wei-Hua,Wang, Hai-Feng,Sun, Liang-Dan,et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2[J]. NATURE GENETICS,2011,43(12):1228-U84.
APA Yue, Wei-Hua.,Wang, Hai-Feng.,Sun, Liang-Dan.,Tang, Fu-Lei.,Liu, Zhong-Hua.,...&Zhang, Dai.(2011).Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.NATURE GENETICS,43(12),1228-U84.
MLA Yue, Wei-Hua,et al."Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2".NATURE GENETICS 43.12(2011):1228-U84.

入库方式： OAI收割

来源：数学与系统科学研究院

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