Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations
文献类型：期刊论文
| 作者 | Li, Q.1 ; Zheng, G.2; Tiwari, R.3
|
| 刊名 | JOURNAL OF APPLIED STATISTICS
 |
| 出版日期 | 2011 |
| 卷号 | 38期号:9页码:1833-1843 |
| 关键词 | case-control genetic associations MAX ordered categorical data robustness score averaging tests trend tests |
| ISSN号 | 0266-4763 |
| DOI | 10.1080/02664763.2010.529881 |
| 英文摘要 | The trend test is often used for the analysis of 2 x K ordered categorical data, in which K pre-specified increasing scores are used. There have been discussions on how to assign these scores and the impact of the outcomes on different scores. The scores are often assigned based on the data-generating model. When this model is unknown, using the trend test is not robust. We discuss the weighted average of a trend test over all scientifically plausible choices of scores or models. This approach is more computationally efficient than a commonly used robust test MAX when K is large. Our discussion is for any ordered 2 x K table, but simulation and applications to real data are focused on case-control genetic association studies. Although there is no single test optimal for all choices of scores, our numerical results show that some score averaging tests can achieve the performance of MAX. |
| 资助项目 | National Young Science Foundation of China[10901155] |
| WOS研究方向 | Mathematics |
| 语种 | 英语 |
| WOS记录号 | WOS:000298921300006 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/12763]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Li, Q. |
| 作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.US Natl Heart Lung & Blood Inst, Off Biostat Res, Bethesda, MD 20892 USA 3.US FDA, Ctr Drug Evaluat & Res, Off Biostat, Silver Spring, MD 20993 USA |
| 推荐引用方式 GB/T 7714 | Li, Q.,Zheng, G.,Tiwari, R.. Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations[J]. JOURNAL OF APPLIED STATISTICS,2011,38(9):1833-1843. |
| APA | Li, Q.,Zheng, G.,&Tiwari, R..(2011).Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations.JOURNAL OF APPLIED STATISTICS,38(9),1833-1843. |
| MLA | Li, Q.,et al."Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations".JOURNAL OF APPLIED STATISTICS 38.9(2011):1833-1843. |
入库方式： OAI收割
来源：数学与系统科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。