An MSE-reduced estimator for the response proportion in a two-stage clinical trial
文献类型：期刊论文
| 作者 | Li, Qizhai
|
| 刊名 | PHARMACEUTICAL STATISTICS
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 10期号:3页码:277-279 |
| 关键词 | truncated binomial distribution clinical trial MLE mean-square error |
| ISSN号 | 1539-1604 |
| DOI | 10.1002/pst.414 |
| 英文摘要 | Two-stage design is very useful in clinical trials for evaluating the validity of a specific treatment regimen. When the second stage is allowed to continue, the method used to estimate the response rate based on the results of both stages is critical for the subsequent design. The often-used sample proportion has an evident upward bias. However, the maximum likelihood estimator or the moment estimator tends to underestimate the response rate. A mean-square error weighted estimator is considered here; its performance is thoroughly investigated via Simon's optimal and minimax designs and Shuster's design. Compared with the sample proportion, the proposed method has a smaller bias, and compared with the maximum likelihood estimator, the proposed method has a smaller mean-square error. Copyright (C) 2010 John Wiley & Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000290626600012 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/12890]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Li, Qizhai |
| 作者单位 | CAS, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qizhai. An MSE-reduced estimator for the response proportion in a two-stage clinical trial[J]. PHARMACEUTICAL STATISTICS,2011,10(3):277-279. |
| APA | Li, Qizhai.(2011).An MSE-reduced estimator for the response proportion in a two-stage clinical trial.PHARMACEUTICAL STATISTICS,10(3),277-279. |
| MLA | Li, Qizhai."An MSE-reduced estimator for the response proportion in a two-stage clinical trial".PHARMACEUTICAL STATISTICS 10.3(2011):277-279. |
入库方式： OAI收割
来源：数学与系统科学研究院
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