Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks
文献类型：期刊论文
| 作者 | Wang, Pei1,2; Lu, Jinhu3 ; Yu, Xinghuo2; Liu, Zengrong4
|
| 刊名 | IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 9期号:3页码:312-320 |
| 关键词 | Bio-molecular network duplication and divergence evolutionary mechanism network growth model network motif |
| ISSN号 | 1932-4545 |
| DOI | 10.1109/TBCAS.2014.2343620 |
| 英文摘要 | Duplication and divergence are two basic evolutionary mechanisms of bio-molecular networks. Real-world bio-molecular networks and their statistical characteristics can be well mimicked by artificial algorithms based on the two mechanisms. Bio-molecular networks consist of network motifs, which act as building blocks of large-scale networks. A fundamental question is how network motifs are evolved from long time evolution and natural selection. By considering the effect of various duplication and divergence strategies, we find that the underlying duplication scheme of the real-world undirected bio-molecular networks would rather follow the anti-preference strategy than the random one. The anti-preference duplication mechanism and the dimerization processes can lead to the formation of various motifs, and robustly conserve proper quantities of motifs in the artificial networks as that in the real-world ones. Furthermore, the anti-preference mechanism and edge deletion divergence can robustly preserve the sparsity of the networks. The investigations reveal the possible evolutionary mechanisms of network motifs in real-world bio-molecular networks, and have potential implications in the design, synthesis and reengineering of biological networks for biomedical purpose. |
| 资助项目 | National Science and Technology Major Project of China[2014ZX10004-001-014] ; National Natural Science Foundation of China[61304151] ; National Natural Science Foundation of China[11172158] ; National Natural Science Foundation of China[11472290] ; National Natural Science Foundation of China[61025017] ; Australia ARC[DP130104765] ; Science Foundation of Henan University[2012YBZR007] ; Science Foundation of Henan University[2013YBRW005] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000356515100002 |
| 出版者 | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/20040]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Wang, Pei |
| 作者单位 | 1.Henan Univ, Sch Math & Informat Sci, Kaifeng 475004, Peoples R China 2.RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic 3001, Australia 3.Chinese Acad Sci, Acad Math & Syst Sci, Inst Syst Sci, Beijing 100190, Peoples R China 4.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Pei,Lu, Jinhu,Yu, Xinghuo,et al. Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks[J]. IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS,2015,9(3):312-320. |
| APA | Wang, Pei,Lu, Jinhu,Yu, Xinghuo,&Liu, Zengrong.(2015).Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks.IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS,9(3),312-320. |
| MLA | Wang, Pei,et al."Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks".IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 9.3(2015):312-320. |
入库方式： OAI收割
来源：数学与系统科学研究院
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