Incorporating Hardy-Weinberg Equilibrium Law to Enhance the Association Strength for Ordinal Trait Genetic Study
文献类型：期刊论文
| 作者 | Zhang, Wei; Li, Qizhai
|
| 刊名 | ANNALS OF HUMAN GENETICS
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 80期号:2页码:102-112 |
| 关键词 | Genetic model proportional odds model score test two-phase procedure association studies |
| ISSN号 | 0003-4800 |
| DOI | 10.1111/ahg.12142 |
| 英文摘要 | The conventional method to examine whether genetic variants are associated with the ordinal traits is the proportional odds model. Such analyses are often conducted by assuming an additive genetic mode of inheritance. However, how the genetic variants influence the risk of occurrence of a disease is impossible to know in practice. Using an improper model might result in a low-power test, thus it reduces the probability of detecting the deleterious genetic markers. To address these concerns, we propose a two-phase procedure (TPP) for ordinal trait genetic studies. In the first phase, we used a linear combination to weight the Hardy-Weinberg equilibrium tests in case groups and formed an omnibus test to classify the genetic models. Then based on the chosen model, the corresponding score test was used to identify the associations. To control the false positive rate, we derived the joint distribution of the test used for selecting the genetic model and that used for identifying the associations. We also obtained the closed forms of two other robust tests, MAX3 and CHI2. Extensive computer simulations were carried out and the results showed that the true selection rates of genetic models are satisfactory and the proposed TPP is more robust than MAX3 and CHI2. Finally, we demonstrated the advantage of our proposed method by applying it to analyse the antibody reactivity to cyclic citrullinated peptides data. |
| 资助项目 | National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Strategic Priority Program of the Chinese Academy of Sciences[XDB13040600] |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000371626400003 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/22201]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Li, Qizhai |
| 作者单位 | Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wei,Li, Qizhai. Incorporating Hardy-Weinberg Equilibrium Law to Enhance the Association Strength for Ordinal Trait Genetic Study[J]. ANNALS OF HUMAN GENETICS,2016,80(2):102-112. |
| APA | Zhang, Wei,&Li, Qizhai.(2016).Incorporating Hardy-Weinberg Equilibrium Law to Enhance the Association Strength for Ordinal Trait Genetic Study.ANNALS OF HUMAN GENETICS,80(2),102-112. |
| MLA | Zhang, Wei,et al."Incorporating Hardy-Weinberg Equilibrium Law to Enhance the Association Strength for Ordinal Trait Genetic Study".ANNALS OF HUMAN GENETICS 80.2(2016):102-112. |
入库方式： OAI收割
来源：数学与系统科学研究院
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