An on-chip model for investigating the interaction between neurons and cancer cells
文献类型：期刊论文
| 作者 | Lei, Yifeng1; Li, Jun1; Wang, Nuoxin1; Yang, Xinglong1; Hamada, Yoh2; Li, Qizhai3 ; Zheng, Wenfu1; Jiang, Xingyu1
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| 刊名 | INTEGRATIVE BIOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:3页码:359-367 |
| ISSN号 | 1757-9694 |
| DOI | 10.1039/c5ib00309a |
| 英文摘要 | Emerging evidence suggests that there is extensive interaction between neurons and cancer cells. However, few model systems have been developed to investigate nerve-cancer cell interaction in vitro. Herein, a high-throughput microfluidic compartmentalized chip is developed to examine the interaction between neurons and cancer cells. The nerve bundles appear to provide a biophysical support for cancer cells and guide their directional migration. The cancers that have high levels of perineural invasion in clinical observations exhibit greater migration along neurites in the on-chip model. The on-chip model allows the screening of compounds which inhibit cancer cell migration along neurites in vitro. The interruption of neurites, the pharmacological blockade of nerve-cancer signaling, effectively attenuates the migration of cancer cells along neurites. This on-chip model provides a useful platform to investigate the dynamic interaction between cancer cells and neurons and can dramatically broaden the chemical space in screening neuron-related drugs for cancers. |
| 资助项目 | CAS[XDA09030305] ; CAS/SAFEA ; NSFC[81361140345] ; NSFC[31470911] ; China Postdoctoral Science Foundation[2014M550672] ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000372256400010 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/22309]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Zheng, Wenfu; Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Tohoku Univ, Grad Sch Med, Dept Nanomed Sci, Sendai, Miyagi 9808575, Japan 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Yifeng,Li, Jun,Wang, Nuoxin,et al. An on-chip model for investigating the interaction between neurons and cancer cells[J]. INTEGRATIVE BIOLOGY,2016,8(3):359-367. |
| APA | Lei, Yifeng.,Li, Jun.,Wang, Nuoxin.,Yang, Xinglong.,Hamada, Yoh.,...&Jiang, Xingyu.(2016).An on-chip model for investigating the interaction between neurons and cancer cells.INTEGRATIVE BIOLOGY,8(3),359-367. |
| MLA | Lei, Yifeng,et al."An on-chip model for investigating the interaction between neurons and cancer cells".INTEGRATIVE BIOLOGY 8.3(2016):359-367. |
入库方式： OAI收割
来源：数学与系统科学研究院
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