Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa
文献类型：期刊论文
| 作者 | Zhang, Li1; Cheng, Yong-Xian2; Liu, Ai-Lin1; Wang, Hai-Di1; Wang, Ya-Ling2; Du, Guan-Hua1 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 15期号:11页码:8507-8517 |
| 关键词 | Chaenomeles Speciosa Antioxidants Anti-inflammatory Na Inhibition |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules15118507 |
| 文献子类 | Article |
| 英文摘要 | The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mu g/mL and 1.27 mu g/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC50 values of 3.82 mu g/mL and 1.90 mu g/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-alpha by 22.73%, 33.14% and 37.19% at 5 mu g/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents. |
| 学科主题 | Chemistry ; Organic |
| WOS关键词 | VIRUS ; GLUCOSIDES ; EXPRESSION ; ARTHRITIS ; CELLS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000284582100070 |
| 资助机构 | Ministry of Science and Technology of China [2009ZX09302-003, 2009ZX09102-123, 2008ZX09401-004]; MOE ; MOHRSS ; Talent Scholarship of Yunnan Youth [2007PY01-48] |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1501]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,et al. Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa[J]. MOLECULES,2010,15(11):8507-8517. |
| APA | Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,Wang, Hai-Di,Wang, Ya-Ling,&Du, Guan-Hua.(2010).Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa.MOLECULES,15(11),8507-8517. |
| MLA | Zhang, Li,et al."Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa".MOLECULES 15.11(2010):8507-8517. |
入库方式： OAI收割
来源：昆明植物研究所
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