A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis
文献类型：期刊论文
| 作者 | Gu, Qiong; Wang, Rui-Rui; Zhang, Xue-Mei ; Wang, Yun-Hua; Zheng, Yong-Tang; Zhou, Jun; Chen, Ji-Jun
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2007-03-01 |
| 卷号 | 73期号:3页码:279-282 |
| 关键词 | Acid-derivatives Betulinic Acid Aids Agents Triterpenes Inhibitors |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-2007-967113 |
| 文献子类 | Article |
| 英文摘要 | A new benzofuran lactone, rhuscholide A (1), was isolated from the stems of Rhus chinensis, together with six known compounds: 5-hydroxy-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11 tetraenyl)-2(3H)-benzofuranone (2), betulin (3), betulonic acid (4), moronic acid (5), 3-oxo-60-hydroxyolean-12-en-28-oic acid (6) and 3-oxo-60-hydroxyolean-18-en-28-oic acid (7). Based on 1D, 2D NMR (COSY, HMQC, HMBC) and mass (EI-MS, HR-EI-MS) spectral data, the structure of rhuscholide A was deduced to be 5-hydroxy-3-(propan-2-ylidene)-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11-tetraenyl)-2(3H)-benzofuranone (1). Anti-HIV-1 bioassays in vitro revealed that compound 1 possesses significant anti-HIV-1 activity with an EC50 value of 1.62 mu M and a therapeutic index (TI) of 42.40. Compounds 2, 4, 5 and 7 showed moderate anti-HIV-1 activities with EC50 values of 3.70, 5.81, 7.49 and 13.11 mu M, respectively. |
| 学科主题 | Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | ACID-DERIVATIVES ; BETULINIC ACID ; AIDS AGENTS ; TRITERPENES ; INHIBITORS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000245588700015 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1525]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Lab Mol Immunopharmacol, Key Lab Anim Models & Human Dis Mech, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Kunming Branch, Joint Lab Anti Viral Nat Med, Kunming, Peoples R China 4.Chinese Acad Sci, Grad Sch, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Qiong,Wang, Rui-Rui,Zhang, Xue-Mei,et al. A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis[J]. PLANTA MEDICA,2007,73(3):279-282. |
| APA | Gu, Qiong.,Wang, Rui-Rui.,Zhang, Xue-Mei.,Wang, Yun-Hua.,Zheng, Yong-Tang.,...&Chen, Ji-Jun.(2007).A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis.PLANTA MEDICA,73(3),279-282. |
| MLA | Gu, Qiong,et al."A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis".PLANTA MEDICA 73.3(2007):279-282. |
入库方式： OAI收割
来源：昆明植物研究所
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