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Flavoalkaloids with a Pyrrolidinone Ring from Chinese Ancient Cultivated Tea Xi-Gui

文献类型：期刊论文

作者Cheng, Jian1; Wu, Fei-Hua3; Wang, Pu3; Ke, Jia-Ping1; Wan, Xiao-Chun1; Qiu, Ming-Hua2; Bao, Guan-Hu1
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2018-08-01
卷号66期号:30页码:7948-7957
关键词etc-pyrrolidinone (-)-epicatechin-O-gallate (ECG) Camellia sinensis (-)-catechin-O-gallate (CG) human umbilical vein endothelia cells (HUVECs)
ISSN号0021-8561
DOI10.1021/acs.jafc.8b02266
英文摘要Chinese Xi-Gui tea is one ancient cultivated variety of Camellia sinensis var. assamica. At present, it is used for producing expensive and elite tea in China. Five new flavoalkaloids, (-)-6-(5 ''' S)-N-ethyl-2-pyrrolidinone-epicatechin-3-O-gallate (ester-type catechins pyrrolidinone E, etc-pyrrolidinone E, 1), (-)-6-(5 ''' R)-N-ethyl-2-pyrrolidinone-epicatechin-3-O-gallate (etc-pyrrolidinone F, 2) (-)-8-(5 ''' S)-N-ethyl-2-pyrrolidinone-epicatechin-3-O-gallate (etc-pyrrolidinone G, 3a), (-)-8(5 ''' S)-N-ethyl-2-pyrrolidinone-catechin-3-O-gallate (etc-pyrrolidinone I, 4a), (-)-8-(5 ''' R)-N-ethyl-2-pyrrolidinone-catechin-3-O-gallate (etc-pyrrolidinone J, 4b), and one new naturally occurring natural product (-)-8-(5 ''' R)-N-ethyl-2-pyrrolidinoneepicatechin-3-O-gallate (etc-pyrrolidinone H, 3b) together with the known flavoalkaloids etc-pyrrolidinones A-D (5, 6, 7a, and 7b) were detected and isolated from Xi-Gui green tea. Their structures were identified by comprehensive NMR spectroscopic analyses. Absolute configurations of 1-3 were established by comparison of the CD analyses with epicatechin-3-O-gallate (ECG). Compounds 1-4 were evaluated for their protection against high glucose induced cell senescence on human umbilical vein endothelia cells (HUVECs) and showed significant protection effects (p < 0.01) at both 1.0 and 10 mu M. A discussion on the possible evolution of tea plants divergent from related food plants on the basis of phytochemical view is also provided.
资助项目The Open Fund of State Key Laboratory of Tea Plant Biology and Utilization[SKLTOF20160108] ; National Modern Agriculture Technology System Grant[CARS-23]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000440876900012
出版者AMER CHEMICAL SOC
资助机构The Open Fund of State Key Laboratory of Tea Plant Biology and Utilization ; National Modern Agriculture Technology System Grant
源URL[http://ir.kib.ac.cn/handle/151853/62068]  
专题中国科学院昆明植物研究所
通讯作者Qiu, Ming-Hua; Bao, Guan-Hu
作者单位1.Anhui Agr Univ, Nat Prod Lab, Int Joint Lab Tea Chem & Hlth Effects, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Jian,Wu, Fei-Hua,Wang, Pu,et al. Flavoalkaloids with a Pyrrolidinone Ring from Chinese Ancient Cultivated Tea Xi-Gui[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(30):7948-7957.
APA Cheng, Jian.,Wu, Fei-Hua.,Wang, Pu.,Ke, Jia-Ping.,Wan, Xiao-Chun.,...&Bao, Guan-Hu.(2018).Flavoalkaloids with a Pyrrolidinone Ring from Chinese Ancient Cultivated Tea Xi-Gui.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(30),7948-7957.
MLA Cheng, Jian,et al."Flavoalkaloids with a Pyrrolidinone Ring from Chinese Ancient Cultivated Tea Xi-Gui".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.30(2018):7948-7957.

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来源：昆明植物研究所

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