Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities
文献类型：期刊论文
| 作者 | Lu, Lu1,2; Chen, Jian-Chao1; Li, Yan1 ; Qing, Chen3; Wang, Yuan-Yuan1; Nian, Yin1,2; Qiu, Ming-Hua1
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| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
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| 出版日期 | 2012-05-01 |
| 卷号 | 60期号:5页码:571-577 |
| 关键词 | Cimicifuga Foetida Cycloartane Cytotoxicity Ranunculaceae |
| ISSN号 | 0009-2363 |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China, mhchiu@mail.kib.ac.cn |
| 文献子类 | Article |
| 英文摘要 | Two new triterpenoids and a chromone glycoside, namely, 24-epi-cimigenol-3-one (1), foetinoside (2), cimifugin-4'-O-[6 ''-feruloyl]-beta-D-glucopyranoside (3), together with 18 known compounds, were isolated from the rhizomes of Cimicifuga foetida L. collected in Guizhou Province, China. All of the compounds were identified by spectroscopic methods, as well as chemical methods. In the in vitro cytotoxicity evaluation of these compounds against 5 human cancer cell lines, cimigenol (8) exerted the most potent cytotoxic activity against SMMC-7721 (7.87 mu M) and A-549 (12.16 mu M), while cimiacerin B (9) also showed obvious cytotoxicity against the A-549 cell line, with an IC50 value of 16.77 mu M. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| WOS关键词 | BREAST-CANCER CELLS ; CRUDE DRUG SHOMA ; RACEMOSA EXTRACT ; SIMPLEX WORMSK ; CYCLOLANOSTANOL XYLOSIDES ; TRITERPENE GLYCOSIDES ; CHEMICAL-CONSTITUENTS ; PROSTATE-CANCER ; AERIAL PARTS ; BLACK COHOSH |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000303293000001 |
| 资助机构 | Foundation of Key State Lab. of Phytochemistry and Plant Resources in West China[P2008ZZ05]; Cooperative Project of Guangdong Province; CAS[2009B09 1300135, KSCX2-YW-G-038, KSCX2-YW-R-194, 29KZCX2-XB2-15-03]; National Natural Science Foundation of China[30772636] |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/10351]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Kunming Med Coll, Kunming 650031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Lu,Chen, Jian-Chao,Li, Yan,et al. Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2012,60(5):571-577. |
| APA | Lu, Lu.,Chen, Jian-Chao.,Li, Yan.,Qing, Chen.,Wang, Yuan-Yuan.,...&Qiu, Ming-Hua.(2012).Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities.CHEMICAL & PHARMACEUTICAL BULLETIN,60(5),571-577. |
| MLA | Lu, Lu,et al."Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities".CHEMICAL & PHARMACEUTICAL BULLETIN 60.5(2012):571-577. |
入库方式： OAI收割
来源：昆明植物研究所
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