Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
文献类型：期刊论文
| 作者 | Federica Facciotti; Gundimeda S Ramanjaneyulu; Marco Lepore; Sebastiano Sansano; Marco Cavallari; Magdalena Kistowska; Sonja Forss-Petter; Guanghui Ni; Alessia Colone; Amit Singhal |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 13期号:5页码:474-U73 |
| 关键词 | Anticancer Drug Garcinia Oligantha Xanthone Apoptosis Caspase-3 Derivatives Activation |
| ISSN号 | 1529-2908 |
| DOI | 10.1038/ni.2245 |
| 通讯作者 | De Libero, G (reprint author), Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland, gennaro_delibero@immunol.a-star.edu.sg |
| 文献子类 | Article |
| 英文摘要 | The development and maturation of semi-invariant natural killer T cells (iNKT cells) rely on the recognition of self antigens presented by CD1d restriction molecules in thymus. The nature of the stimulatory thymic self lipids remains elusive. We isolated lipids from thymocytes and found that ether-bonded mono-alkyl glycerophosphates and the precursors and degradation products of plasmalogens stimulated iNKT cells. Synthetic analogs showed high potency in activating thymic and peripheral iNKT cells. Mice deficient in the peroxisomal enzyme glyceronephosphate O-acyltransferase (GNPAT), essential for the synthesis of ether lipids, had significant alteration of the thymic maturation of iNKT cells and fewer iNKT cells in both thymus and peripheral organs, which confirmed the role of ether-bonded lipids as iNKT cell antigens. Thus, peroxisome-derived lipids are nonredundant self antigens required for the generation of a full iNKT cell repertoire. |
| 学科主题 | Immunology |
| WOS关键词 | V-ALPHA-14 NKT CELLS ; MICE ; CD1D ; GLYCOSPHINGOLIPIDS ; BIOSYNTHESIS ; RECOGNITION ; LIGANDS ; INFLAMMATION ; PLASMALOGENS ; HOMEOSTASIS |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000303048400011 |
| 资助机构 | Swiss National Foundation[3100AO-122464/1, Sinergia CRS133-124819]; Yunnan High-End Technology Professionals Introduction Program[2010CI117]; Oncosuisse |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/10361]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Federica Facciotti,Gundimeda S Ramanjaneyulu,Marco Lepore,et al. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus[J]. NATURE IMMUNOLOGY,2012,13(5):474-U73. |
| APA | Federica Facciotti.,Gundimeda S Ramanjaneyulu.,Marco Lepore.,Sebastiano Sansano.,Marco Cavallari.,...&Gennaro De Libero.(2012).Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus.NATURE IMMUNOLOGY,13(5),474-U73. |
| MLA | Federica Facciotti,et al."Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus".NATURE IMMUNOLOGY 13.5(2012):474-U73. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。