Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)
文献类型：期刊论文
| 作者 | Adebayo, A. H.1,2; Tan, N. H.1; Akindahunsi, A. A.3; Zeng, G. Z.1; Zhang, Y. M.1 |
| 刊名 | PHARMACOGNOSY MAGAZINE
 |
| 出版日期 | 2010 |
| 卷号 | 6期号:21页码:62-66 |
| 关键词 | Ageratum Conyzoides Anticancer Antiradical Scavenging Activity Cytotoxicity |
| DOI | 10.4103/0973-1296.59968 |
| 文献子类 | Article |
| 英文摘要 | Ageratum conyzoides has been used in folklore for the treatment of a wide range of diseases. In the present investigation, the in vitro activity of ethanol, petroleum ether, ethylacetate, butanol, and water extracts of A. conyzoides were screened in some cancer cell lines using the sulphorhodamine B (SRB) assay. These cell lines include: Human non-small cell lung carcinoma (A-549), human colon adenocarcinoma (HT-29), human gastric carcinoma (SGC-7901), human golima (U-251), human breast carcinoma (MDA-MB-231), human prostate carcinoma (DU-145), human hepatic carcinoma (BEL-7402), and mouse leukemia (P-388) cancer cell lines. Furthermore, kaempferol was isolated from the ethylacetate extract and the structure was elucidated by nuclear magnetic resonance (NMR) and mass spectroscopy. The effect of DPPH antiradical activity on the extracts and kaempferol was also determined. The results showed that ethylacetate extract exhibited the highest cytotoxic activity on A-549 and P-388 cancer cells with IC(50) values of 0.68 and 0.0003 mu g/ml, respectively. Kaempferol isolated from the ethylacetate extract of A. conyzoides rapidly scavenged DPPH at a concentration of 130.07 +/- 17.36 g/kg. The result therefore showed that A. conyzoides possessed anticancer and antiradical properties. |
| 学科主题 | Chemistry, Medicinal |
| WOS关键词 | INHIBITORS ; DISCOVERY ; APOPTOSIS ; PLANTS ; CELLS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000276883000011 |
| 公开日期 | 2012-07-25 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/14471]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria 3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria |
| 推荐引用方式 GB/T 7714 | Adebayo, A. H.,Tan, N. H.,Akindahunsi, A. A.,et al. Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)[J]. PHARMACOGNOSY MAGAZINE,2010,6(21):62-66. |
| APA | Adebayo, A. H.,Tan, N. H.,Akindahunsi, A. A.,Zeng, G. Z.,&Zhang, Y. M..(2010).Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae).PHARMACOGNOSY MAGAZINE,6(21),62-66. |
| MLA | Adebayo, A. H.,et al."Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)".PHARMACOGNOSY MAGAZINE 6.21(2010):62-66. |
入库方式： OAI收割
来源：昆明植物研究所
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