Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole
文献类型：期刊论文
| 作者 | Chen, Wen1,2,3; Yang, Xiao-Dong1; Li, Yan4 ; Yang, Li-Juan2,3; Wang, Xue-Quan1; Zhang, Gao-Lan1; Zhang, Hong-Bin1
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:11页码:4250-4255 |
| 关键词 | Biological Evaluation Antitumor-activity Derivatives Iodides Analogs Lignans Trans Dna |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c1ob05116d |
| 通讯作者 | Zhang, HB (reprint author), Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity. |
| 学科主题 | Chemistry |
| WOS关键词 | BIOLOGICAL EVALUATION ; ANTITUMOR-ACTIVITY ; DERIVATIVES ; IODIDES ; ANALOGS ; LIGNANS ; TRANS ; DNA |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000290735300037 |
| 资助机构 | National Natural Science Foundation of China[30960460, 20925205, 20832005]; National Basic Research Program of China (973 Program)[2009CB522300] |
| 公开日期 | 2012-07-25 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/14477]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China 2.Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China 3.Yunnan Univ Nationalities, Sch Chem & Biotechnol, Minist Educ, Kunming 650031, Peoples R China 4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wen,Yang, Xiao-Dong,Li, Yan,et al. Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(11):4250-4255. |
| APA | Chen, Wen.,Yang, Xiao-Dong.,Li, Yan.,Yang, Li-Juan.,Wang, Xue-Quan.,...&Zhang, Hong-Bin.(2011).Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole.ORGANIC & BIOMOLECULAR CHEMISTRY,9(11),4250-4255. |
| MLA | Chen, Wen,et al."Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole".ORGANIC & BIOMOLECULAR CHEMISTRY 9.11(2011):4250-4255. |
入库方式： OAI收割
来源：昆明植物研究所
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