Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata
文献类型：期刊论文
| 作者 | Jiang, B; Hou, AJ; Li, ML; Li, SH ; Han, QB; Wang, SJ; Lin, ZW; Sun, HD
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2002-10-01 |
| 卷号 | 68期号:10页码:921-925 |
| 关键词 | Isodon Sculponeata Labiatae Diterpenoids Sculponeatins F-i Cytotoxicity |
| 文献子类 | Article |
| 英文摘要 | Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodo-sin (6), epi-nodosinol (7), enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some di-terpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC50 values ranging from 3.2 mug/ml to 8.2 mug/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000178977000012 |
| 公开日期 | 2012-07-25 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/14585]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China 3.Dali Med Coll, Dept Pharmaceut, Dali, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, B,Hou, AJ,Li, ML,et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata[J]. PLANTA MEDICA,2002,68(10):921-925. |
| APA | Jiang, B.,Hou, AJ.,Li, ML.,Li, SH.,Han, QB.,...&Sun, HD.(2002).Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata.PLANTA MEDICA,68(10),921-925. |
| MLA | Jiang, B,et al."Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata".PLANTA MEDICA 68.10(2002):921-925. |
入库方式： OAI收割
来源：昆明植物研究所
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