中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata

文献类型:期刊论文

作者Jiang, B; Hou, AJ; Li, ML; Li, SH; Han, QB; Wang, SJ; Lin, ZW; Sun, HD
刊名PLANTA MEDICA
出版日期2002-10-01
卷号68期号:10页码:921-925
关键词Isodon Sculponeata Labiatae Diterpenoids Sculponeatins F-i Cytotoxicity
文献子类Article
英文摘要Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodo-sin (6), epi-nodosinol (7), enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some di-terpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC50 values ranging from 3.2 mug/ml to 8.2 mug/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.
学科主题Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000178977000012
公开日期2012-07-25
源URL[http://ir.kib.ac.cn:8080/handle/151853/14585]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
3.Dali Med Coll, Dept Pharmaceut, Dali, Peoples R China
推荐引用方式
GB/T 7714
Jiang, B,Hou, AJ,Li, ML,et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata[J]. PLANTA MEDICA,2002,68(10):921-925.
APA Jiang, B.,Hou, AJ.,Li, ML.,Li, SH.,Han, QB.,...&Sun, HD.(2002).Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata.PLANTA MEDICA,68(10),921-925.
MLA Jiang, B,et al."Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata".PLANTA MEDICA 68.10(2002):921-925.

入库方式: OAI收割

来源:昆明植物研究所

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