A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis
文献类型：期刊论文
| 作者 | Jiang, Zhi-Yong; Zhang, Xue-Mei ; Zhang, Feng-Xue; Liu, Ni; Zhao, Fang; Zhou, Jun; Chen, Ji-Jun
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2006-08-01 |
| 卷号 | 72期号:10页码:951-954 |
| 关键词 | Protostane-type Triterpenes Absolute Stereostructures Aquatic Plants Crude Drugs Rhizoma Sesquiterpenes Constituents 23-acetate Alismoxide |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-2006-947178 |
| 文献子类 | Article |
| 英文摘要 | A new triterpencid named alisol 0 (1) was isolated from the rhizomes of Alisma orientalis, together with six known compounds: alisol A 24-acetate (2), 25-anhydroalisol A (3),13 beta,17 beta-epoxyalisol A (4), alisol B 23-acetate (5), alisol F (6), and alisol F 24-acetate (7). Based on 1D and 2D-NMR data (HMQC, HMBC, COSY, ROESY), the structure of the new compound was deduced to be 11-dehydroxy-12-dehydroalisol F-24-acetate (1). Compounds 2-7 exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 2.3,11.0,15.4,14.3, 0.6 and 7.7 mu M, and on HBV e antigen (HBeAg) secretion with IC50 values of 498.1, 17.6, 41.0,19.9, 8.5 and 5.1 mu M, respectively. |
| 学科主题 | Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | PROTOSTANE-TYPE TRITERPENES ; ABSOLUTE STEREOSTRUCTURES ; AQUATIC PLANTS ; CRUDE DRUGS ; RHIZOMA ; SESQUITERPENES ; CONSTITUENTS ; 23-ACETATE ; ALISMOXIDE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000240478500019 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1583]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Guangzhou Univ Chinese Tradit Med, Inst Trop Med Sci, Guangzhou, Peoples R China 3.Chinese Acad Sci, Joint Lab Anti Viral Nat Med, Kunming Branch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhi-Yong,Zhang, Xue-Mei,Zhang, Feng-Xue,et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis[J]. PLANTA MEDICA,2006,72(10):951-954. |
| APA | Jiang, Zhi-Yong.,Zhang, Xue-Mei.,Zhang, Feng-Xue.,Liu, Ni.,Zhao, Fang.,...&Chen, Ji-Jun.(2006).A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis.PLANTA MEDICA,72(10),951-954. |
| MLA | Jiang, Zhi-Yong,et al."A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis".PLANTA MEDICA 72.10(2006):951-954. |
入库方式： OAI收割
来源：昆明植物研究所
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