New glycosides from Tetracentron sinense and their cytotoxic activity
文献类型：期刊论文
| 作者 | Wang, Yi-Fen ; Lai, Gou-Fang; Efferth, Thomas; Cao, Jian-Xin; Luo, Shi-De
|
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2006 |
| 卷号 | 3期号:9页码:1023-1030 |
| 关键词 | Multidrug-resistance Cell Lines Transporter Artesunate Glucosides Triterpene Bark |
| ISSN号 | 1612-1872 |
| 文献子类 | Article |
| 英文摘要 | One novel neolignan (tetracentronsine; 1), one new indole alkaloid (= 3-(2-hydroxyethyl)-1H-indole-5-O-beta-D-glucopyranoside; 2), and two new phenol derivatives, 3-{2-[(beta-glucopyranosyl)oxy]-4,5(methylenedioxy)phenyl}propanoic acid (3) and methyl 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoate (4), together with six known compounds were isolated from the stem bark of Tetracentron sinense. Their structures were determined by spectral analysis, including 1D- and 2D-NMR, and MS analyses. These compounds were tested for their cytotoxic activity against human leukaemia cells in vitro. Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multi drug-resistant sub-line, CEM/ADR5000, with IC50, values in a range of 7.1 to 29.7 mu m. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry ; Multidisciplinary |
| WOS关键词 | MULTIDRUG-RESISTANCE ; CELL LINES ; TRANSPORTER ; ARTESUNATE ; GLUCOSIDES ; TRITERPENE ; BARK |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000241317500010 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1617]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.German Canc Res Ctr, D-69120 Heidelberg, Germany |
| 推荐引用方式 GB/T 7714 | Wang, Yi-Fen,Lai, Gou-Fang,Efferth, Thomas,et al. New glycosides from Tetracentron sinense and their cytotoxic activity[J]. CHEMISTRY & BIODIVERSITY,2006,3(9):1023-1030. |
| APA | Wang, Yi-Fen,Lai, Gou-Fang,Efferth, Thomas,Cao, Jian-Xin,&Luo, Shi-De.(2006).New glycosides from Tetracentron sinense and their cytotoxic activity.CHEMISTRY & BIODIVERSITY,3(9),1023-1030. |
| MLA | Wang, Yi-Fen,et al."New glycosides from Tetracentron sinense and their cytotoxic activity".CHEMISTRY & BIODIVERSITY 3.9(2006):1023-1030. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。