Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton
文献类型：期刊论文
| 作者 | Han, Quan-Bin; Cheung, Susan; Tai, Joseph; Qiao, Chun-Feng; Song, Jing-Zheng; Tso, Ting-Fai; Sun, Han-Dong ; Xu, Hong-Xi
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2006-10-12 |
| 卷号 | 8期号:21页码:4727-4730 |
| 关键词 | Ent-kaurane Diterpenoids Rubescens Var.-taihangensis Dimer Laxiflora Oridonin Crystal |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol061757j |
| 文献子类 | Article |
| 英文摘要 | A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC(50) = 2.90, 1.63, and 1.45 mu g/mL and with camptothecin and paclitaxel as the positive controls. |
| 学科主题 | Chemistry ; Organic |
| WOS关键词 | ENT-KAURANE DITERPENOIDS ; RUBESCENS VAR.-TAIHANGENSIS ; DIMER ; LAXIFLORA ; ORIDONIN ; CRYSTAL |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000241030900015 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1649]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Hong Kong, Hong Kong, Peoples R China 2.Univ British Columbia, Ctr Complementary Med Res, Child & Family Res Inst, Dept Pathol, Vancouver, BC V5Z 1M9, Canada 3.Univ British Columbia, Ctr Complementary Med Res, Child & Family Res Inst, Dept Pediat, Vancouver, BC V5Z 1M9, Canada 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Quan-Bin,Cheung, Susan,Tai, Joseph,et al. Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton[J]. ORGANIC LETTERS,2006,8(21):4727-4730. |
| APA | Han, Quan-Bin.,Cheung, Susan.,Tai, Joseph.,Qiao, Chun-Feng.,Song, Jing-Zheng.,...&Xu, Hong-Xi.(2006).Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton.ORGANIC LETTERS,8(21),4727-4730. |
| MLA | Han, Quan-Bin,et al."Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton".ORGANIC LETTERS 8.21(2006):4727-4730. |
入库方式： OAI收割
来源：昆明植物研究所
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