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New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas

文献类型：期刊论文

作者Yang, Yuan-Feng1,2; Liu, Jie-Qing1; Li, Zhong-Rong1; Li, Yan1; Qiu, Ming-Hua1,2
刊名FITOTERAPIA
出版日期2013-09-01
卷号89页码:278-284
关键词Jatropha Curcas Euphorbiaceae Sesquiterpenoid Germacranolide Eudesmanolide Cytotoxicity
ISSN号0367-326X
通讯作者Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China. ; mhchiu@mail.kib.ac.cn
文献子类Article
英文摘要Three new eudesmenoic acid methyl esters (1-3), as well as five known compounds, including three germacranolides (4-6) and two eudesmanolides (7 and 8), were isolated from the seed oil of Jatropha curcas. The new compounds were elucidated by means of spectroscopic methods, including extensive NMR spectra. In addition, the structure of 8 was confirmed by a single-crystal X-ray diffraction analysis. Among the isolates, compounds 4-6 were the first reported from the genus Jatropha. Using MTS viability assay, the cytotoxicity of compounds 2-8 were evaluated against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines. Compounds 4 and 5 showed remarkable cytotoxicity against all the tested cell lines with IC50 values from 0.5 to 3.5 mu M, and the new compound 3 displayed selective cytotoxic activity against A-549 cell with an IC50 value of 7.24 mu M, but slight cytotoxicity against HL-60 and MCF-7 with IC50 values of 23.77 and 22.37 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved.
学科主题Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词SESQUITERPENE LACTONES ; 12-DEOXY-16-HYDROXYPHORBOL ; CONSTITUENTS ; PYRETHROSIN ; ARTEMISIA
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000323856500033
资助机构Chinese Ministry of Science and Technology [2007BAD32B01-03, SB2007FY400]; National Natural Science Foundation of China [81202437]; National Knowledge Innovation Program of Chinese Academy of Sciences [KSCX2-YW-G-038]
公开日期2013-10-16
源URL[http://ir.kib.ac.cn:8080/handle/151853/16681]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,et al. New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas[J]. FITOTERAPIA,2013,89:278-284.
APA Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,Li, Yan,&Qiu, Ming-Hua.(2013).New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas.FITOTERAPIA,89,278-284.
MLA Yang, Yuan-Feng,et al."New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas".FITOTERAPIA 89(2013):278-284.

入库方式： OAI收割

来源：昆明植物研究所

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