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Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity

文献类型：期刊论文

作者Li, Shi-Fei1,2; Zhang, Yu1; Huang, Ning2,3; Zheng, Yong-Tang3; Di, Ying-Tong1; Li, Shun-Lin1; Cheng, Yuan-Yuan1,2; He, Hong-Ping1; Hao, Xiao-Jiang1
刊名PHYTOCHEMISTRY
出版日期2013-09-01
卷号93页码:216-221
关键词Trigonostemon Lii Euphorbiaceae Daphnane Diterpenoids Trigolins A-g Anti-hiv-1 Activity
ISSN号0031-9422
DOI10.1016/j.phytochem.2013.03.003
通讯作者He, HP (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; hehongping@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
文献子类Article
英文摘要Thirteen highly oxygenated daphnane diterpenoids, including six known compounds, were isolated from the stems of Trigonostemon lii. The structures were elucidated by extensive spectroscopic analyses including 2D NMR spectroscopy (HSQC, H-1-H-1 COSY, HMBC, and ROESY) and mass spectrometry. The absolute stereochemistries of compounds were established on the basis of CD spectra. Four of the compounds showed modest anti-HIV-1 activity (EC50 = 2.04, 9.17, 11.42, and 9.05 mu g/ml, TI = 26.49, >21.81, 9.32, and 9.56, respectively) in vitro. (C) 2013 Elsevier Ltd. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Plant Sciences
WOS关键词SYNAPTOLEPIS-KIRKII ; POTENT ; REIDIOIDES ; ORTHOESTER
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000323630000025
资助机构Ministry of Science and Technology of China [2009CB522300, 2009CB940900]; National Natural Science Funding of China [21072199]; Natural Science Funding of Yunnan Province [2009CD112]; Foundation of Chinese Academy of Sciences; Yong Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047] ; Ministry of Science and Technology of China(2009CB522300 ; National Natural Science Funding of China(21072199) ; Natural Science Funding of Yunnan Province(2009CD112) ; Foundation of Chinese Academy of Sciences ; Yong Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047) ; 2009CB940900)
公开日期2013-10-16
源URL[http://ir.kib.ac.cn:8080/handle/151853/16685]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming 650223, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shi-Fei,Zhang, Yu,Huang, Ning,et al. Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity[J]. PHYTOCHEMISTRY,2013,93:216-221.
APA Li, Shi-Fei.,Zhang, Yu.,Huang, Ning.,Zheng, Yong-Tang.,Di, Ying-Tong.,...&Hao, Xiao-Jiang.(2013).Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity.PHYTOCHEMISTRY,93,216-221.
MLA Li, Shi-Fei,et al."Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity".PHYTOCHEMISTRY 93(2013):216-221.

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来源：昆明植物研究所

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