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Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction

文献类型：期刊论文

作者Hu, Rongkuan1,2; Yan, Huan3; Hao, Xiaojiang3; Liu, Haiyang3; Wu, Jiarui1,2,4,5
刊名PLOS ONE
出版日期2013-08-14
卷号8期号:8页码:e73527
关键词Activated Protein-kinase Fatty-acid Oxidation Respiratory Complex-i Insulin-resistance Malonyl-coa Signaling Pathways Glucose-uptake L6 Myotubes Hepg2 Cells Metformin
ISSN号1932-6203
通讯作者Liu, HY (reprint author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China. ; haiyangliu@mail.kib.ac.cn ; wujr@sibs.ac.cn
文献子类Article
英文摘要This study is the first to demonstrate that shizukaol D, a natural compound isolated from Chloranthus japonicus, can activate AMP-activated protein kinase (AMPK), a key sensor and regulator of intracellular energy metabolism, leading to a decrease in triglyceride and cholesterol levels in HepG2 cells. Furthermore, we found that shizukaol D induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation. Our results provide a possible link between mitochondrial dysfunction and AMPK activation and suggest that shizukaol D might be used to treat metabolic syndrome.
学科主题Multidisciplinary Sciences
WOS关键词ACTIVATED PROTEIN-KINASE ; FATTY-ACID OXIDATION ; RESPIRATORY COMPLEX-I ; INSULIN-RESISTANCE ; MALONYL-COA ; SIGNALING PATHWAYS ; GLUCOSE-UPTAKE ; L6 MYOTUBES ; HEPG2 CELLS ; METFORMIN
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000323221500147
资助机构Ministry of Science and Technology [2010CB912102, 2011CB910200]; National Natural Science Foundation of China [31130034]; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-Q-10]
公开日期2013-10-16
源URL[http://ir.kib.ac.cn:8080/handle/151853/16703]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,et al. Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction[J]. PLOS ONE,2013,8(8):e73527.
APA Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,Liu, Haiyang,&Wu, Jiarui.(2013).Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction.PLOS ONE,8(8),e73527.
MLA Hu, Rongkuan,et al."Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction".PLOS ONE 8.8(2013):e73527.

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来源：昆明植物研究所

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