Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds
文献类型：期刊论文
| 作者 | Chen, Wen1; Deng, Xiao-Yan1; Li, Yan2 ; Yang, Li-Juan3,4; Wan, Wei-Chao1; Wang, Xue-Quan1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2013-08-01 |
| 卷号 | 23期号:15页码:4297-4302 |
| 关键词 | Hybrid Compound Benzofuran Imidazole Triazole Structure-activity Relationships |
| ISSN号 | 0960-894X |
| 通讯作者 | Yang, XD (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; xdyang120@gmail.com |
| 文献子类 | Article |
| 英文摘要 | A series of novel hybrid compounds of 2-phenyl-3-alkylbenzofuran and imidazole or triazole were prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the 2-ethyl-imidazole ring, and substitution of the imidazolyl-3-position with a 2-bromobenzyl or naphthylacyl group, were vital for modulating inhibitory activity. In particular, hybrid compound 31 was found to be the most potent derivative with IC50 values of 0.08-0.55 mu M against five strains human tumor cell lines and was found to be more selective against breast carcinoma (MCF-7) and colon carcinoma (SW480) (IC50 values 40.8-fold and 40.1-fold lower than cisplatin (DDP)). (C) 2013 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Organic |
| WOS关键词 | ANTITUMOR-ACTIVITY ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; DESIGN ; DERIVATIVES ; BENZOFURANS ; IODIDES ; ANALOGS ; TRANS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000321495900003 |
| 资助机构 | NSFC [30960460, 20925205, 21062026]; NSFYN [2010GA014, 2012FB113]; PRTTSTYN [2009C1120]; NBRPC (973 Program) [2009CB522300] |
| 公开日期 | 2013-10-16 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/16727]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China 4.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wen,Deng, Xiao-Yan,Li, Yan,et al. Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(15):4297-4302. |
| APA | Chen, Wen.,Deng, Xiao-Yan.,Li, Yan.,Yang, Li-Juan.,Wan, Wei-Chao.,...&Yang, Xiao-Dong.(2013).Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(15),4297-4302. |
| MLA | Chen, Wen,et al."Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.15(2013):4297-4302. |
入库方式： OAI收割
来源：昆明植物研究所
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