Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production
文献类型：期刊论文
| 作者 | Xu, Junju1,2; Su, Jia1; Li, Yan1 ; Tan, Ninghua1
|
| 刊名 | CHEMISTRY OF NATURAL COMPOUNDS
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 49期号:3页码:457-461 |
| 关键词 | Zingiberaceae Alpinia Oxyphylla Eremophilane Sesquiterpene Oxyphyllanone a Inhibition Of No Production |
| ISSN号 | 0009-3130 |
| 通讯作者 | Xu, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; nhtan@mail.kib.ac.cn |
| 文献子类 | Article |
| 英文摘要 | Phytochemical investigation of the fruits of Alpinia oxyphylla led to the isolation of 12 eremophilane sesquiterpenes, including a novel noreremophilane sesquiterpene, (4R*,5R*)-7-acetyl-4,5-dimethyl-4,5,8,9-tetrahydronaphthalen-2(3H)-one (oxyphyllanone A, 1), along with eleven known compounds (2-12). Among them, compounds 2-6, 9, and 11 were isolated from this genus for the first time. Their structures were determined on the basis of spectroscopic analysis, including 2D NMR spectroscopic techniques. The tested compounds 2-12 showed different inhibitory activity against NO production in interferon-gamma- and lipopolysaccharide-induced RAW264.7 macrophage cells, and compound 11 was the most active one with IC50 value of 4.61 mu g/mL. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Organic |
| WOS关键词 | ABSOLUTE STEREOSTRUCTURES ; BIOTRANSFORMATION ; VALENCENE ; CELLS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000322679200014 |
| 资助机构 | National Natural Science Foundation of China [U1032602, 31000159, 91013002, 30725048]; National New Drug Innovation Major Project of China [2011ZX09307-002-002]; National Basic Research Program of China [2009CB522300] |
| 公开日期 | 2013-10-16 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/16743]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Junju,Su, Jia,Li, Yan,et al. Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production[J]. CHEMISTRY OF NATURAL COMPOUNDS,2013,49(3):457-461. |
| APA | Xu, Junju,Su, Jia,Li, Yan,&Tan, Ninghua.(2013).Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production.CHEMISTRY OF NATURAL COMPOUNDS,49(3),457-461. |
| MLA | Xu, Junju,et al."Eremophilane-type sesquiterpenes from Alpinia oxyphylla with inhibitory activity against nitric oxide production".CHEMISTRY OF NATURAL COMPOUNDS 49.3(2013):457-461. |
入库方式： OAI收割
来源：昆明植物研究所
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