Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii
文献类型:期刊论文
作者 | Zhan, Rui1,2; Li, Xiao-Nian1; Du, Xue1; Wang, Wei-Guang1; Dong, Ke1; Su, Jia1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1 |
刊名 | JOURNAL OF NATURAL PRODUCTS |
出版日期 | 2013-07-01 |
卷号 | 76期号:7页码:1267-1277 |
ISSN号 | 0163-3864 |
关键词 | Lasiocarpus Hayata Kudo Nf-kappa-b Leukemic-cells Terpenoids Rubescens Differentiation Cytotoxicity Constituents Pharicin |
通讯作者 | Pu, JX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
文献子类 | Article |
英文摘要 | Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects by several of the compounds tested. Furthermore, 12 of the isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages. |
学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
WOS关键词 | LASIOCARPUS HAYATA KUDO ; NF-KAPPA-B ; LEUKEMIC-CELLS ; TERPENOIDS ; RUBESCENS ; DIFFERENTIATION ; CYTOTOXICITY ; CONSTITUENTS ; PHARICIN |
WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000322562900007 |
资助机构 | National Natural Science Foundation of China [81172939]; Major State Basic Research Development Program of China [2009CB522300]; reservation-talent project of Yunnan Province [2011CI043]; Science and Technology Program of Yunnan Province [2008IF010]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences |
公开日期 | 2013-10-16 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/16745] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Zhan, Rui,Li, Xiao-Nian,Du, Xue,et al. Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(7):1267-1277. |
APA | Zhan, Rui.,Li, Xiao-Nian.,Du, Xue.,Wang, Wei-Guang.,Dong, Ke.,...&Sun, Han-Dong.(2013).Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii.JOURNAL OF NATURAL PRODUCTS,76(7),1267-1277. |
MLA | Zhan, Rui,et al."Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii".JOURNAL OF NATURAL PRODUCTS 76.7(2013):1267-1277. |
入库方式: OAI收割
来源:昆明植物研究所
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