A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata
文献类型：期刊论文
| 作者 | Huang Sheng-Dian1,2; Zhang Yu1 ; He Hong-Ping1; Li Shi-Fei1,2; Tang Gui-Hua1,2; Chen Duo-Zhi1,2; Cao Ming-Ming1,2; Di Ying-Tong1; Hao Xiao-Jiang1
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 11期号:4页码:406-410 |
| 关键词 | Lycoris Radiata Amaryllidaceae Alkaloids Homolycorine-type 2 Alpha-methoxy-6-o-methyloduline 2 Alpha-methoxy-6-beta-ethyloduline |
| ISSN号 | 1672-3651 |
| DOI | 10.3724/SP.J.1009.2013.00406 |
| 通讯作者 | Hao, XJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; diyt@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata. METHODS: The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A. RESULTS: One new homolycorine-type alkaloid 2 alpha-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2 alpha-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6 alpha-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained. CONCLUSION: Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 mu g.mL(-1) and CC50 values of 14.37, 4.79, and 80.12 mu g.ml(-1), respectively. |
| 学科主题 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| WOS关键词 | RACEMIC LYCORAMINE ; HOSTA-PLANTAGINEA ; DL-LYCORAMINE ; NARCISSUS ; GALANTHAMINE |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000322299000012 |
| 资助机构 | National Natural Science Foundation of China [30830114]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2009CI072] ; National Natural Science Foundation of China(30830114) ; Young Academic and Technical Leader Raising Foundation of Yunnan Province(2009CI072) |
| 公开日期 | 2013-10-16 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/16753]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang Sheng-Dian,Zhang Yu,He Hong-Ping,et al. A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2013,11(4):406-410. |
| APA | Huang Sheng-Dian.,Zhang Yu.,He Hong-Ping.,Li Shi-Fei.,Tang Gui-Hua.,...&Hao Xiao-Jiang.(2013).A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata.CHINESE JOURNAL OF NATURAL MEDICINES,11(4),406-410. |
| MLA | Huang Sheng-Dian,et al."A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata".CHINESE JOURNAL OF NATURAL MEDICINES 11.4(2013):406-410. |
入库方式： OAI收割
来源：昆明植物研究所
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