Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors
文献类型：期刊论文
| 作者 | Zhang, Quan1,3; Jiang, Zhi-Yong1; Luo, Jie1; Cheng, Pi1,3; Ma, Yun-Bao1; Zhang, Xue-Mei1 ; Zhang, Feng-Xue2; Zhou, Jun1; Chen, Ji-Jun1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2008-08-15 |
| 卷号 | 18期号:16页码:4647-4650 |
| 关键词 | Anti-hbv Activity Alisol a Derivatives Synthesis |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2008.07.012 |
| 文献子类 | Article |
| 英文摘要 | A series of alisol A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in vitro. The preliminary investigation demonstrates that simple modifications of the parent structure of alisol A can produce a number of potentially important derivatives against HBV. The most active anti-HBV compound 6a showed high activities against the secretion of HBV surface antigen (IC(50) = 0.024 mM), HBV e antigen (IC(50) = 0.028 mM) and remarkable selective indices (SI(HBsAg) > 108, SI(HBeAg) > 93), which was selected for further evaluation as a novel HBV inhibitor. (C) 2008 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry ; Medicinal ; Chemistry ; Organic |
| WOS关键词 | PROTOSTANE-TYPE TRITERPENES ; CHINESE ALISMATIS RHIZOMA ; ABSOLUTE STEREOSTRUCTURES ; LAMIVUDINE THERAPY ; DRIED RHIZOME ; AIDS AGENTS ; ORIENTALE ; 23-ACETATE ; CONSTITUENTS ; TERPENOIDS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000258769200044 |
| 资助机构 | National Natural Science Foundation of China [30672522]; Xibu Zhiguang Joint-Scholarship ; Chinese Academy of Sciences [KSCX1-YW-R-24] |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1703]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Guangxi Univ Tradit Chinese Med, Inst Trop Med Sci, Guangzhou, Guangdong, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Quan,Jiang, Zhi-Yong,Luo, Jie,et al. Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(16):4647-4650. |
| APA | Zhang, Quan.,Jiang, Zhi-Yong.,Luo, Jie.,Cheng, Pi.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2008).Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(16),4647-4650. |
| MLA | Zhang, Quan,et al."Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.16(2008):4647-4650. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。