Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea
文献类型：期刊论文
| 作者 | Zhang, Ying; Li, Hai-Zhou; Zhang, Ying-Jun ; Jacob, Melissa R.; Khan, Shabana I.; Li, Xing-Cong; Yang, Chong-Ren
|
| 刊名 | STEROIDS
 |
| 出版日期 | 2006-08-01 |
| 卷号 | 71期号:8页码:712-719 |
| 关键词 | Smilacina Atropurpurea Steroidal Saponins Atropurosides A-f Antifungal Activities Cytotoxicity |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2006.04.005 |
| 文献子类 | Article |
| 英文摘要 | Atropurosides A-G (1-7), seven new steroidal saponins, which possess new polyhydroxylated aglycones, were isolated from the rhizomes of Smilacina atropurpurea (Convallariaceae), together with a known saponin, dioscin (8). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. Antifungal testing of the eight compounds indicated that atropurosides B (2) and F (6) were fungicidal against Candida albicans, Candida glabrata, Cryptococcus neoformans, and Aspergillus fumigatus with minimum fungicidal concentrations (MFCs) <= 20 mu g/ml, while dioscin (8) was selectively active against C. albicans and C. glabrata (MFC < 5.0 mu g/ml). Furthermore, the antifungal saponins 2, 6, and 8 were evaluated for their in vitro cytotoxicities in a panel of human cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3, and HepG2) and noncancerous Vero cells. All showed moderate cytotoxicities. It appears that the antifungal activity of these steroidal saponins correlates with their cytotoxicity against mammalian cells. (c) 2006 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS关键词 | SAPOGENINS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000239224300010 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1835]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Ying,Li, Hai-Zhou,Zhang, Ying-Jun,et al. Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea[J]. STEROIDS,2006,71(8):712-719. |
| APA | Zhang, Ying.,Li, Hai-Zhou.,Zhang, Ying-Jun.,Jacob, Melissa R..,Khan, Shabana I..,...&Yang, Chong-Ren.(2006).Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea.STEROIDS,71(8),712-719. |
| MLA | Zhang, Ying,et al."Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea".STEROIDS 71.8(2006):712-719. |
入库方式： OAI收割
来源：昆明植物研究所
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