ent-labdane diterpenoid lactone stereoisomers from Andrographis paniculata
文献类型：期刊论文
| 作者 | Chen, Lixia1; Zhu, Huajie2; Wang, Rui3; Zhou, Kailan1; Jing, Yongkui4; Qiu, Feng1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 71期号:5页码:852-855 |
| 关键词 | Ray Crystallographic Analysis Minor Diterpenoids Nees |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np0704452 |
| 文献子类 | Article |
| 英文摘要 | Two pairs of ent-labdane diterpenoid lactone stereoisomers (1-4) including three new compounds (1-3) were isolated from the 85% EtOH extract of the aerial parts of Andrographis paniculata. The structures of these compounds were identified as 7R-hydroxy-14-deoxyandrographolide (1), 7S-hydroxy-14-deoxyandrographolide (2), 12S,13S-hydroxyandrographolide (3), and 12R,13R-hydroxyandrographolide (4) by spectroscopic data analyses and calculated (13)C NMR data at the B3LYP/6-311++G(2d,p)//B3LYP/6-31G* level using the GIAO method. The 12S-configuration of 4 was revised to 12R based on the spectroscopic data. The antiproliferative activities of the two pairs of stereoisomers and 14 other ent-labdane diterpenoid derivatives were determined in human leukemia HL-60 cells. Andrographolide (7) and isoandrographolide (12) exhibited higher antiproliferative activities than other ent-labdane diterpenoids with GI(50)'s of 9.33 and 6.30 mu M, respectively. |
| 学科主题 | Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | RAY CRYSTALLOGRAPHIC ANALYSIS ; MINOR DITERPENOIDS ; NEES |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000256180600022 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1867]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China 2.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 4.Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA |
| 推荐引用方式 GB/T 7714 | Chen, Lixia,Zhu, Huajie,Wang, Rui,et al. ent-labdane diterpenoid lactone stereoisomers from Andrographis paniculata[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(5):852-855. |
| APA | Chen, Lixia,Zhu, Huajie,Wang, Rui,Zhou, Kailan,Jing, Yongkui,&Qiu, Feng.(2008).ent-labdane diterpenoid lactone stereoisomers from Andrographis paniculata.JOURNAL OF NATURAL PRODUCTS,71(5),852-855. |
| MLA | Chen, Lixia,et al."ent-labdane diterpenoid lactone stereoisomers from Andrographis paniculata".JOURNAL OF NATURAL PRODUCTS 71.5(2008):852-855. |
入库方式： OAI收割
来源：昆明植物研究所
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