Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia
文献类型：期刊论文
| 作者 | Chen, Jianchao1,3; Tian, Renrong2; Qiu, Minghua1 ; Lu, Lu1,3; Zheng, Yongtang2; Zhang, Zhongquan1,3
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2008-02-01 |
| 卷号 | 69期号:4页码:1043-1048 |
| 关键词 | Momordica Charantia Cucurbitaceae Roots Kuguacins A-e Trinorcucurbitane Triterpenoids Anti-hiv-1 |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2007.10.020 |
| 文献子类 | Article |
| 英文摘要 | Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3 beta,7 beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3 beta,25-dihydroxy-5 beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 mu g/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50) > 200 mu g/ml), with a selectivity index more than 23.68 and 7.81, respectively. (C) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
| WOS关键词 | BITTER PRINCIPLES ; IMMATURE FRUITS ; GLYCOSIDES ; CONSTITUENTS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000254149800025 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1891]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jianchao,Tian, Renrong,Qiu, Minghua,et al. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia[J]. PHYTOCHEMISTRY,2008,69(4):1043-1048. |
| APA | Chen, Jianchao,Tian, Renrong,Qiu, Minghua,Lu, Lu,Zheng, Yongtang,&Zhang, Zhongquan.(2008).Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia.PHYTOCHEMISTRY,69(4),1043-1048. |
| MLA | Chen, Jianchao,et al."Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia".PHYTOCHEMISTRY 69.4(2008):1043-1048. |
入库方式： OAI收割
来源：昆明植物研究所
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