Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea
文献类型：期刊论文
| 作者 | Wang, Yue-Hu ; Gao, Suo; Yang, Fu-Mei; Sun, Qian-Yun; Wang, Jun-Song; Liu, Hai-Yang; Li, Chun-Shun; Di, Ying-Tong; Li, Shun-Lin; He, Hong-Ping
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2007-12-06 |
| 卷号 | 9期号:25页码:5279-5281 |
| 关键词 | Amaryllidaceae Alkaloids Sceletium Alkaloids Acetylcholinesterase Assay Transformation |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol702438h |
| 文献子类 | Article |
| 英文摘要 | Hostasinine A (1), a benzylphenethylamine alkaloid with an unprecedented skeleton featuring a C-4-C-6 linkage and a nitrone moiety, was isolated from Hosta plantaginea. Its structure was established on the basis of spectroscopic data, and was further confirmed by single-crystal X-ray diffraction. The alkaloid was postulated biogenetically from haemanthidine via N-oxidation and aza-aldol-type condensation and was synthesized biomimetically. The inhibitory activities of 1 on acetylcholinesterase (AM) and two tumor cell lines (K562 and A549) were also evaluated. |
| 学科主题 | Chemistry ; Organic |
| WOS关键词 | AMARYLLIDACEAE ALKALOIDS ; SCELETIUM ALKALOIDS ; ACETYLCHOLINESTERASE ; ASSAY ; TRANSFORMATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000251313000035 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/1945]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Key Lab Chem Nat Prod, Guiyang 550002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yue-Hu,Gao, Suo,Yang, Fu-Mei,et al. Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea[J]. ORGANIC LETTERS,2007,9(25):5279-5281. |
| APA | Wang, Yue-Hu.,Gao, Suo.,Yang, Fu-Mei.,Sun, Qian-Yun.,Wang, Jun-Song.,...&Hao, Xiao-Jiang.(2007).Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea.ORGANIC LETTERS,9(25),5279-5281. |
| MLA | Wang, Yue-Hu,et al."Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea".ORGANIC LETTERS 9.25(2007):5279-5281. |
入库方式： OAI收割
来源：昆明植物研究所
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