Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase
文献类型：期刊论文
| 作者 | Wang, Yue-Hu ; Zhang, Zhong-Kai; Yang, Fu-Mei; Sun, Qian-Yun; He, Hong-Ping; Di, Ying-Tong; Mu, Shu-Zhen; Lu, Yang; Chang, Ying; Zheng, Qi-Tai
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2007-09-01 |
| 卷号 | 70期号:9页码:1458-1461 |
| 关键词 | Amaryllidaceae Alkaloids Cytostatic Activity Steroidal Saponins Hl-60 Cells Hymenocallis Ungeremine Plants Bulbs |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np0702077 |
| 文献子类 | Article |
| 英文摘要 | Five new benzylphenethylamine alkaloids, hostasine (1), 8-demethoxyhostasine, 8-demethoxy-10-O-methylhostasine, 10-O-methylhostasirie, and 9-O-demethyl-7-O-methyllycorenine, along with 12 known compounds, were isolated from Hosta plantaginea by bioassay-guided fractionation. The structures of the new alkaloids were established by means of extensive spectroscopic methods, and the relative configuration of I was further confirmed by single-crystal X-ray diffraction. 7-Deoxy-trans-dihydronarciclasine (IC50 = 1.80 mu M), a known alkaloid, showed strong activity against tobacco mosaic virus by the half-leaf method. Some of these alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase. 8-Demethoxy-10-O-methylhostasine was found to possess significant activity, with an IC50 of 2.32 mu M. |
| 学科主题 | Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | AMARYLLIDACEAE ALKALOIDS ; CYTOSTATIC ACTIVITY ; STEROIDAL SAPONINS ; HL-60 CELLS ; HYMENOCALLIS ; UNGEREMINE ; PLANTS ; BULBS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000249871200013 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/2005]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Yunnan Acad Agr Sci, Yunnan Key Lab Agr Biotechnol, Kunming 650223, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China 5.Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China 6.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yue-Hu,Zhang, Zhong-Kai,Yang, Fu-Mei,et al. Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(9):1458-1461. |
| APA | Wang, Yue-Hu.,Zhang, Zhong-Kai.,Yang, Fu-Mei.,Sun, Qian-Yun.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2007).Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.JOURNAL OF NATURAL PRODUCTS,70(9),1458-1461. |
| MLA | Wang, Yue-Hu,et al."Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase".JOURNAL OF NATURAL PRODUCTS 70.9(2007):1458-1461. |
入库方式： OAI收割
来源：昆明植物研究所
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