Synthesis and cytotoxicity of some new eriocalyxin B derivatives
文献类型：期刊论文
| 作者 | Zhao, Yu; Niu, Xue-Mei; Qian, Li-Ping; Liu, Ze-Yuan; Zhao, Qin-Shi ; Sun, Han-Dong
|
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2007-04-01 |
| 卷号 | 42期号:4页码:494-502 |
| 关键词 | Eriocalyxin b Synthesis Cytotoxicity Sar |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2006.11.004 |
| 文献子类 | Article |
| 英文摘要 | Eriocalyxin B (1) was regarded as the promising candidate for new anticancer agent because of its potent activity and novel mechanism of action. Systematic modifications of 1 were done, and nineteen derivatives were synthesized and their cytotoxicities against five tumor cell lines were evaluated. The structure-activity relationship (SAR) of 1 confirmed that the alpha,beta-unsaturated ketone moieties in ring A and D are the leading active sites; the 7,20-epoxy moiety, OH-6 and OH-7 play an important role in keeping the cytotoxicity. The 6,7-seco derivative 19 had remarkable activity while derivative 20 oxidized from 19 was completely inactive, which suggested that the carboxyl group could destroy the cytoxicity of 20 despite the presence of alpha,beta-unsaturated ketone moiety. (c) 2006 Elsevier Masson SAS. All rights reserved. |
| 学科主题 | Chemistry ; Medicinal |
| WOS关键词 | ENT-KAURANE DITERPENOIDS ; ISODON-ERIOCALYX ; RUBESCENS ; BINDING |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000246268500009 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/2093]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Acad Mil Med Sci, Affiliated Hosp, Dept Clin Pharmacol, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yu,Niu, Xue-Mei,Qian, Li-Ping,et al. Synthesis and cytotoxicity of some new eriocalyxin B derivatives[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2007,42(4):494-502. |
| APA | Zhao, Yu,Niu, Xue-Mei,Qian, Li-Ping,Liu, Ze-Yuan,Zhao, Qin-Shi,&Sun, Han-Dong.(2007).Synthesis and cytotoxicity of some new eriocalyxin B derivatives.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,42(4),494-502. |
| MLA | Zhao, Yu,et al."Synthesis and cytotoxicity of some new eriocalyxin B derivatives".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 42.4(2007):494-502. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。